Sex Differences in Clinical and Genetic Determinants of Levodopa Peak-Dose Dyskinesias in Parkinson Disease: An Exploratory Study

• Published in: Archives of neurology (Chicago) Vol. 62; no. 4; pp. 601 - 605
• Main Authors: Zappia, Mario, Annesi, Grazia, Nicoletti, Giuseppe, Arabia, Gennarina, Annesi, Ferdinanda, Messina, Demetrio, Pugliese, Pierfrancesco, Spadafora, Patrizia, Tarantino, Patrizia, Carrideo, Sara, Civitelli, Donatella, De Marco, Elvira V, Cirò-Candiano, Innocenza C, Gambardella, Antonio, Quattrone, Aldo
• Format: Journal Article
• Language: English
• Published: Chicago, IL American Medical Association 01.04.2005
• Subjects: Age of Onset; Aged; Antiparkinson Agents - adverse effects; Biological and medical sciences; Clinical outcomes; Cohort Studies; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; DNA Mutational Analysis; DNA Repeat Expansion - genetics; Dose-Response Relationship, Drug; Drug toxicity and drugs side effects treatment; Dyskinesia, Drug-Induced - genetics; Dyskinesia, Drug-Induced - metabolism; Dyskinesia, Drug-Induced - physiopathology; Female; Gender differences; Genetic Predisposition to Disease - genetics; Genetic Testing; Genotype; Health risk assessment; Humans; Levodopa - adverse effects; Male; Medical sciences; Multivariate Analysis; Neurology; Parkinson Disease - drug therapy; Parkinson's disease; Pharmacology. Drug treatments; Polymorphism, Genetic - genetics; Predictive Value of Tests; Receptors, Dopamine D2 - genetics; Sex Characteristics; Toxicity: nervous system and muscle; Nervous system diseases; Central nervous system disease; Sex; Parkinson disease; Degenerative disease; Levodopa; Neurological disorder; Cerebral disorder; Extrapyramidal syndrome; Involuntary movement; Dyskinesia

BACKGROUND Several factors, both clinical and genetic, may account for the risk of developing levodopa-induced peak-dose dyskinesias (PDD) in patients with Parkinson disease, but it is unclear how these factors interact for modulating the individual susceptibility for PDD. OBJECTIVE To examine clini...