“Electron Transport Chain Interference” Strategy of Amplified Mild-Photothermal Therapy and Defect-Engineered Multi-Enzymatic Activities for Synergistic Tumor-Personalized Suppression

• Published in: Journal of the American Chemical Society Vol. 145; no. 17; pp. 9488 - 9507
• Main Authors: Dong, Shuming, Dong, Yushan, Zhao, Zhiyu, Liu, Jing, Liu, Shikai, Feng, Lili, He, Fei, Gai, Shili, Xie, Ying, Yang, Piaoping
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 03.05.2023
• Subjects: absorption; acidity; adjuvants; apoptosis; cancer therapy; catalytic activity; Cell Line, Tumor; density functional theory; Electron Transport; electron transport chain; ferroptosis; heat; heat stress; heat tolerance; Humans; Hydrogen Peroxide; NAD; Nanoparticles - therapeutic use; neoplasms; Neoplasms - therapy; oxidation; Phototherapy - methods; Photothermal Therapy; synergism; Tumor Microenvironment
• ISSN: 0002-7863; 1520-5126; 1520-5126
• DOI: 10.1021/jacs.2c09608

Arming activatable mild-photothermal therapy (PTT) with the property of relieving tumor thermotolerance holds great promise for overcoming traditional mild PTT limitations such as thermoresistance, insufficient therapeutic effect, and off-target heating. Herein, a mitochondria-targeting, defect-engi...