Supramolecular Photosensitizer Enables Oxygen-Independent Generation of Hydroxyl Radicals for Photodynamic Therapy

• Published in: Journal of the American Chemical Society Vol. 145; no. 7; pp. 4081 - 4087
• Main Authors: Teng, Kun-Xu, Niu, Li-Ya, Yang, Qing-Zheng
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 22.02.2023
• Subjects: cytotoxicity; electron transfer; hydrogen bonding; hydroxyl radicals; irradiation; mice; photochemotherapy; photosensitizing agents; pyruvic acid

The highly oxygen-dependent nature of photodynamic therapy (PDT) limits its therapeutic efficacy against hypoxic solid tumors in clinics, which is an urgent problem to be solved. Herein, we develop an oxygen-independent supramolecular photodynamic agent that produces hydroxyl radical (•OH) by oxidiz...