Asymmetric Intramolecular Amination Catalyzed with CpIr-SPDO via Nitrene Transfer for Synthesis of Spiro-Quaternary Indolinone

• Published in: Journal of the American Chemical Society Vol. 146; no. 28; pp. 18841 - 18847
• Main Authors: Wei, Shi-Qiang, Li, Zi-Hao, Wang, Shuang-Hu, Chen, Hua, Wang, Xiao-Yu, Gu, Yun-Zhou, Zhang, Ye, Wang, Hong, Ding, Tong-Mei, Zhang, Shu-Yu, Tu, Yong-Qiang
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 17.07.2024; Amer Chemical Soc
• Subjects: amination; azides; catalysts; Chemistry; Chemistry, Multidisciplinary; enols; ligands; Physical Sciences; Science & Technology; CROSS-COUPLING REACTIONS; INSERTION; AZIRIDINATION; ACCESS

An asymmetric intramolecular spiro-amination to high steric hindering α-C–H bond of 1,3-dicarbonyl via nitrene transfer using inactive aryl azides has been carried out by developing a novel Cp*Ir­(III)-SPDO (spiro-pyrrolidine oxazoline) catalyst, thereby enabling the first successful construction of...