Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor - Tanada, Mikimasa; Tamiya, Minoru; Matsuo, Atsushi; Chiyoda, Aya; Takano, Koji; Ito, Toshiya; Irie, Machiko; Kotake, Tomoya; Takeyama, Ryuuichi; Kawada, Hatsuo; Hayashi, Ryuji; Ishikawa, Shiho; et al. (Journal of the American Chemical Society, 2023)
Keywords: absorption; bioavailability; Chemistry; Chemistry, Multidisciplinary; cyclic peptides; drugs; membrane permeability; Physical Sciences; protein structure; Science & Technology; therapeutics; CHAIN; PERMEABILITY; SMALL-MOLECULE INHIBITORS; DRUG DISCOVERY; MESSENGER-RNA DISPLAY; BINDING; CYCLOSPORINE; INSIGHTS