Structure of the Major G‑Quadruplex in the Human EGFR Oncogene Promoter Adopts a Unique Folding Topology with a Distinctive Snap-Back Loop

• Published in: Journal of the American Chemical Society Vol. 145; no. 29; pp. 16228 - 16237
• Main Authors: Liu, Yushuang, Li, Jinzhu, Zhang, Yongqiang, Wang, Yingying, Chen, Juannan, Bian, Yuting, Xia, Yuanzheng, Yang, Ming-Hua, Zheng, Kewei, Wang, Kai-Bo, Kong, Ling-Yi
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 26.07.2023
• Subjects: cancer therapy; colorectal neoplasms; DNA; DNA-directed DNA polymerase; glioblastoma; hepatoma; humans; hydrogen; oncogenes; promoter regions; topology; tyrosine

EGFR tyrosine kinase inhibitors have made remarkable success in targeted cancer therapy. However, therapeutic resistance inevitably occurred and EGFR-targeting therapy has been demonstrated to have limited efficacy or utility in glioblastoma, colorectal cancer, and hepatocellular carcinoma. Therefor...