Two-in-One Chemogene Assembled from Drug-Integrated Antisense Oligonucleotides To Reverse Chemoresistance

• Published in: Journal of the American Chemical Society Vol. 141; no. 17; pp. 6955 - 6966
• Main Authors: Mou, Quanbing, Ma, Yuan, Ding, Fei, Gao, Xihui, Yan, Deyue, Zhu, Xinyuan, Zhang, Chuan
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 01.05.2019
• Subjects: animal models; antineoplastic activity; DNA; drug delivery systems; drug resistance; drug therapy; floxuridine; gene expression regulation; gene therapy; liver transplant; neoplasms; oligonucleotides; resistance genes; thymine; transfection

Combinatorial chemo and gene therapy provides a promising way to cure drug-resistant cancer, since the codelivered functional nucleic acids can regulate drug resistance genes, thus restoring sensitivity of the cells to chemotherapeutics. However, the dramatic chemical and physical differences betwee...