Covalent Organic Framework Embedded with Magnetic Nanoparticles for MRI and Chemo-Thermotherapy

• Published in: Journal of the American Chemical Society Vol. 142; no. 44; pp. 18782 - 18794
• Main Authors: Benyettou, Farah, Das, Gobinda, Nair, Anjana Ramdas, Prakasam, Thirumurugan, Shinde, Digambar B, Sharma, Sudhir Kumar, Whelan, Jamie, Lalatonne, Yoann, Traboulsi, Hassan, Pasricha, Renu, Abdullah, Osama, Jagannathan, Ramesh, Lai, Zhiping, Motte, Laurence, Gándara, Felipe, Sadler, Kirsten C, Trabolsi, Ali
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 04.11.2020
• Subjects: Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - metabolism; Antineoplastic Agents - pharmacology; aqueous solutions; Cell Line, Tumor; Cell Survival - drug effects; cytotoxicity; Danio rerio; doxorubicin; Doxorubicin - chemistry; Doxorubicin - metabolism; Doxorubicin - pharmacology; Drug Carriers - chemistry; Embryo, Nonmammalian - drug effects; endosomes; Ferric Compounds - chemistry; fever; glioblastoma; heat transfer; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Hyperthermia, Induced; Imines - chemistry; lysine; lysosomes; magnetic fields; Magnetic Resonance Imaging; Magnetite Nanoparticles - chemistry; Nanoparticles - chemistry; Polylysine - chemistry; polymers; Porosity; Temperature; Zebrafish - growth & development

Nanoscale imine-linked covalent organic frameworks (nCOFs) were first loaded with the anticancer drug Doxorubicin (Dox), coated with magnetic iron oxide nanoparticles (γ-Fe2O3 NPs), and stabilized with a shell of poly­(l-lysine) cationic polymer (PLL) for simultaneous synergistic thermo-chemotherapy...