Straightforward Access to a Great Diversity of Complex Biorelevant γ‑Lactams Thanks to a Tunable Cascade Multicomponent Process

• Published in: Organic process research & development Vol. 24; no. 5; pp. 606 - 614
• Main Authors: Mardjan, Muhammad Idham Darussalam, Mayooufi, Atef, Parrain, Jean-Luc, Thibonnet, Jérôme, Commeiras, Laurent
• Format: Journal Article
• Language: English
• Published: American Chemical Society 15.05.2020
• Subjects: Chemical Sciences; Organic chemistry; lactams; copper catalysis; γ-hydroxybutyrolactams; heterocyclic compounds; multicomponent reaction; spirolactams

This reviews surveys the preparation of a great diversity of complex biorelevant γ-lactam backbones thanks to scalable copper­(I)-catalyzed cascade multicomponent processes.