On-DNA Cross-Dehydrogenative Coupling Reaction toward the Synthesis of Focused DNA-Encoded Tetrahydroisoquinoline Libraries

• Published in: Organic letters Vol. 22; no. 15; pp. 5721 - 5725
• Main Authors: Wen, Xin, Duan, Zhiqiang, Liu, Jiaxiang, Lu, Weiwei, Lu, Xiaojie
• Format: Journal Article
• Language: English
• Published: American Chemical Society 07.08.2020
• Subjects: alkynes; Lewis bases; tetrahydroisoquinolines

To expand the chemical space of DNA-encoded library (DEL) technology, we have developed the DNA-compatible cross-dehydrogenative coupling reaction between tetrahydroisoquinolines (THIQs) and a series of nucleophiles such as nitromethane, terminal alkynes, and so on. Both photo- and metal-promoted co...