Ni-Catalyzed Reductive Arylcyanation of Alkenes

• Published in: Organic letters Vol. 23; no. 16; pp. 6466 - 6470
• Main Authors: Li, Hengxu, Chen, Jiachang, Dong, Jueqi, Kong, Wangqing
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 20.08.2021; Amer Chemical Soc
• Subjects: alkaloids; alkenes; Chemistry; Chemistry, Organic; enantioselectivity; Physical Sciences; rapid methods; Science & Technology; CYANATING AGENT; ARYL-ALKENYLATION; NITRILES; CYCLIZATION

We disclose a Ni-catalyzed reductive arylcyanation of alkene using environmentally benign and nontoxic organo cyanating reagent N-cyano-N-phenyl-p-toluenesulfonamide. This reaction provides a new method for the rapid synthesis of cyano-substituted oxindoles and isoquinoline-1,3-diones and features h...