Antiallergic agents. 3. N-(1H-tetrazol-5-yl)-2-pyridinecarboxamides

• Published in: Journal of medicinal chemistry Vol. 27; no. 2; pp. 125 - 128
• Main Authors: Honma, Yasushi, Hanamoto, Kyoji, Hashiyama, Tomiki, Sekine, Yasuo, Takeda, Mikio, Ono, Yasutoshi, Tsuzurahara, Kei
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 01.02.1984
• Subjects: Animals; Biological Assay; Chemical Phenomena; Chemistry; Hypersensitivity - drug therapy; Niacinamide - analogs & derivatives; Niacinamide - chemical synthesis; Niacinamide - pharmacology; Passive Cutaneous Anaphylaxis - drug effects; Rats; Structure-Activity Relationship

A series of N-tetrazolylpyridinecarboxamides was prepared and evaluated for antiallergic activity by the passive cutaneous anaphylaxis (PCA) assay. From the structure-activity relationships (SAR) of this class of compounds, it was revealed that the N-tetrazolylcarbamoyl group as an acidic functional...