Role of Metabolic Activation in 8‑Epidiosbulbin E Acetate-Induced Liver Injury: Mechanism of Action of the Hepatotoxic Furanoid

• Published in: Chemical research in toxicology Vol. 29; no. 3; pp. 359 - 366
• Main Authors: Lin, Dongju, Li, Weiwei, Peng, Ying, Jiang, Chunfeng, Xu, Youjun, Gao, Huiyuan, Zheng, Jiang
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 21.03.2016
• Subjects: Activation, Metabolic - drug effects; Animals; Chemical and Drug Induced Liver Injury - etiology; Chemical and Drug Induced Liver Injury - metabolism; Chemical and Drug Induced Liver Injury - pathology; Chemical and Drug Induced Liver Injury - prevention & control; Cytochrome P-450 Enzyme System - metabolism; Diterpenes - administration & dosage; Diterpenes - metabolism; Diterpenes - toxicity; Dose-Response Relationship, Drug; Ketoconazole - administration & dosage; Ketoconazole - pharmacology; Male; Mice; Mice, Inbred Strains; Molecular Structure; Time Factors

8-Epidiosbulbin E acetate (EEA), a furanoid, was unexpectedly found to be the most abundant diterpenoid lactone in certain varieties of Dioscorea bulbifera L. (DB), a traditional herbal medicine widely used in Asian nations. This herb has been reported to cause liver injury in humans and experimenta...