Solubility properties in polymers and biological media. 2. The correlation and prediction of the solubilities of nonelectrolytes in biological tissues and fluids

• Published in: Journal of medicinal chemistry Vol. 28; no. 7; pp. 865 - 870
• Main Authors: Abraham, Michael H, Kamlet, Mortimer J, Taft, R. W, Doherty, Ruth M, Weathersby, Paul K
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 01.07.1985
• Subjects: Adipose Tissue; Body Fluids; Brain; Gases - blood; Humans; Kidney; Liver; Lung; Mathematics; Muscles; Oils; Solubility; Solvents; Water

Solubilities of a range of nonelectrolyte solutes in biological systems, such as blood, plasma, brain, lung, liver, kidney, muscle tissue, and human fat, are correlated and predicted through an equation that takes the form log Ltissue = c + w log Lwater + o log Loil, where L is the Ostwald solubilit...