Mechanism of Inhibition of the Reproduction of SARS-CoV‑2 and Ebola Viruses by Remdesivir

• Published in: Biochemistry (Easton) Vol. 60; no. 24; pp. 1869 - 1875
• Main Authors: Wang, Jimin, Reiss, Krystle, Shi, Yuanjun, Lolis, Elias, Lisi, George P, Batista, Victor S
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 22.06.2021
• Subjects: Adenosine Monophosphate - analogs & derivatives; Adenosine Monophosphate - genetics; Adenosine Monophosphate - metabolism; Alanine - analogs & derivatives; Alanine - genetics; Alanine - metabolism; antiviral agents; Antiviral Agents - metabolism; Base Pairing; cell lines; chemistry; Coronavirus RNA-Dependent RNA Polymerase - antagonists & inhibitors; Coronavirus RNA-Dependent RNA Polymerase - genetics; Coronavirus RNA-Dependent RNA Polymerase - metabolism; Ebolavirus; Ebolavirus - drug effects; Enzyme Inhibitors - metabolism; exoribonucleases; Models, Molecular; nucleosides; Protein Biosynthesis - drug effects; protein synthesis; reproduction; RNA - genetics; RNA - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; RNA, Viral - genetics; RNA, Viral - metabolism; SARS-CoV-2 - drug effects; Severe acute respiratory syndrome coronavirus 2; Virus Replication - drug effects

Remdesivir is an antiviral drug initially designed against the Ebola virus. The results obtained with it both in biochemical studies in vitro and in cell line assays in vivo were very promising, but it proved to be ineffective in clinical trials. Remdesivir exhibited far better efficacy when repurpo...