Rationally Modulate the Oxidase-like Activity of Nanoceria for Self-Regulated Bioassays
One of the current challenges in nanozyme-based technology is to rationally control the enzyme mimicking activities with suitable modulation strategies to mimic the complexity and functions of natural systems. In this regard, nanoceria has recently emerged as a promising nanozyme because of its uniq...
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| Published in | ACS sensors Vol. 1; no. 11; pp. 1336 - 1343 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
American Chemical Society
23.11.2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 2379-3694 2379-3694 |
| DOI | 10.1021/acssensors.6b00500 |
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| Abstract | One of the current challenges in nanozyme-based technology is to rationally control the enzyme mimicking activities with suitable modulation strategies to mimic the complexity and functions of natural systems. In this regard, nanoceria has recently emerged as a promising nanozyme because of its unique enzyme mimicking properties. Herein, we demonstrated that the oxidase-like catalytic activity of nanoceria was rationally modulated in situ via proton-producing/consuming enzyme-catalyzed bioreactions, which formed the basis of self-regulated bioassays for determining the corresponding enzyme activity, as well as other important targets, such as nerve agents, drugs, and bioactive ions. More interestingly, the oxidase-like activity of nanoceria was cooperatively modulated with the aid of adenosine triphosphate, thus improving the analytical performance of such self-regulated bioassays. The current study not only demonstrated regulatory strategies to modulate the nanozymes’ activities, but also established a facile approach to designing self-regulated bioassays. |
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| AbstractList | One of the current challenges in nanozyme-based technology is to rationally control the enzyme mimicking activities with suitable modulation strategies to mimic the complexity and functions of natural systems. In this regard, nanoceria has recently emerged as a promising nanozyme because of its unique enzyme mimicking properties. Herein, we demonstrated that the oxidase-like catalytic activity of nanoceria was rationally modulated in situ via proton-producing/consuming enzyme-catalyzed bioreactions, which formed the basis of self-regulated bioassays for determining the corresponding enzyme activity, as well as other important targets, such as nerve agents, drugs, and bioactive ions. More interestingly, the oxidase-like activity of nanoceria was cooperatively modulated with the aid of adenosine triphosphate, thus improving the analytical performance of such self-regulated bioassays. The current study not only demonstrated regulatory strategies to modulate the nanozymes’ activities, but also established a facile approach to designing self-regulated bioassays. |
| Author | Cheng, Hanjun Wei, Hui Lin, Ying-Wu Lin, Shichao Muhammad, Faheem |
| AuthorAffiliation | University of South China Collaborative Innovation Center of Chemistry for Life Sciences, State Key Laboratory of Analytical Chemistry for Life Science Nanjing University Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures School of Chemistry and Chemical Engineering |
| AuthorAffiliation_xml | – name: Collaborative Innovation Center of Chemistry for Life Sciences, State Key Laboratory of Analytical Chemistry for Life Science – name: School of Chemistry and Chemical Engineering – name: Nanjing University – name: University of South China – name: Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures |
| Author_xml | – sequence: 1 givenname: Hanjun surname: Cheng fullname: Cheng, Hanjun – sequence: 2 givenname: Shichao surname: Lin fullname: Lin, Shichao – sequence: 3 givenname: Faheem surname: Muhammad fullname: Muhammad, Faheem – sequence: 4 givenname: Ying-Wu surname: Lin fullname: Lin, Ying-Wu – sequence: 5 givenname: Hui surname: Wei fullname: Wei, Hui email: weihui@nju.edu.cn |
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| Snippet | One of the current challenges in nanozyme-based technology is to rationally control the enzyme mimicking activities with suitable modulation strategies to... |
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| Title | Rationally Modulate the Oxidase-like Activity of Nanoceria for Self-Regulated Bioassays |
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