Highly Pathogenic H5N1 and Novel H7N9 Influenza A Viruses Induce More Profound Proteomic Host Responses than Seasonal and Pandemic H1N1 Strains

• Published in: Journal of proteome research Vol. 14; no. 11; pp. 4511 - 4523
• Main Authors: Simon, Philippe François, McCorrister, Stuart, Hu, Pingzhao, Chong, Patrick, Silaghi, Alex, Westmacott, Garrett, Coombs, Kevin M, Kobasa, Darwyn
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 06.11.2015
• Subjects: Cell Line, Tumor; Cell Nucleus - metabolism; Cell Nucleus - virology; Computational Biology - methods; Cytosol - metabolism; Cytosol - virology; Epithelial Cells - metabolism; Epithelial Cells - virology; Fibronectins - genetics; Fibronectins - metabolism; Gene Expression Regulation; Host-Pathogen Interactions; Humans; Influenza A Virus, H1N1 Subtype - physiology; Influenza A Virus, H5N1 Subtype - pathogenicity; Influenza A Virus, H5N1 Subtype - physiology; Influenza A Virus, H7N9 Subtype - pathogenicity; Influenza A Virus, H7N9 Subtype - physiology; NF-E2-Related Factor 2 - genetics; NF-E2-Related Factor 2 - metabolism; Oxidative Stress; Phosphorylation; Protein Transport; Proteome - genetics; Proteome - metabolism; Respiratory Mucosa - metabolism; Respiratory Mucosa - virology; Signal Transduction; Virulence; H5N1; avian influenza; fibronectin; NRF2; FN1; H7N9; H1N1; oxidative stress

Influenza A viruses (IAV) are important human and animal pathogens with potential for causing pandemics. IAVs exhibit a wide spectrum of clinical illness in humans, from relatively mild infections by seasonal strains to acute respiratory distress syndrome during infections with some highly pathogeni...