Utility of Novel Plasma Metabolic Markers in the Diagnosis of Pediatric Tuberculosis: A Classification and Regression Tree Analysis Approach

• Published in: Journal of proteome research Vol. 15; no. 9; pp. 3118 - 3125
• Main Authors: Sun, Lin, Li, Jie-qiong, Ren, Na, Qi, Hui, Dong, Fang, Xiao, Jing, Xu, Fang, Jiao, Wei-wei, Shen, Chen, Song, Wen-qi, Shen, A-dong
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 02.09.2016
• Subjects: Betaine - analysis; Biomarkers - blood; Case-Control Studies; Child; Discriminant Analysis; Humans; Magnetic Resonance Spectroscopy; Metabolome; Metabolomics - methods; Plasma - metabolism; Pyruvic Acid - analysis; Sensitivity and Specificity; Tuberculosis - diagnosis; Valine - analysis; diagnosis; NMR; plasma; metabolomics; children; tuberculosis

Although tuberculosis (TB) has been the greatest killer due to a single infectious disease, pediatric TB is still hard to diagnose because of the lack of sensitive biomarkers. Metabolomics is increasingly being applied in infectious diseases. But little is known regarding metabolic biomarkers in chi...