Long Distance Electron-Transfer Mechanism in Peptidylglycine α-Hydroxylating Monooxygenase:  A Perfect Fitting for a Water Bridge

• Published in: Journal of the American Chemical Society Vol. 129; no. 38; pp. 11700 - 11707
• Main Authors: de la Lande, Aurélien, Martí, Sergio, Parisel, Olivier, Moliner, Vicent
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 26.09.2007
• Subjects: Amino Acids - chemistry; Binding Sites; Biomimetics - methods; Catalysis; Computational Biology; Copper - chemistry; Copper - metabolism; Cytochromes b5 - chemistry; Cytochromes b5 - metabolism; Electron Transport; Hydrogen Bonding; Kinetics; Mixed Function Oxygenases - chemistry; Mixed Function Oxygenases - metabolism; Molecular Structure; Multienzyme Complexes - chemistry; Multienzyme Complexes - metabolism; Quantum Theory; Water - chemistry; Water - metabolism

The active sites of copper enzymes have been the subject of many theoretical and experimental investigations from a number of years. Such studies have embraced topics devoted to the modeling of the first coordination sphere at the metallic cations up to the development of biomimetic, or bioinspired,...