Synthesis of 3‘,5‘-Dipeptidyl Oligonucleotides

• Published in: Journal of organic chemistry Vol. 64; no. 13; pp. 4749 - 4761
• Main Authors: Schwope, Ina, Bleczinski, Colleen F, Richert, Clemens
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 25.06.1999; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; PHOSPHODIESTER BOND; SOLID-PHASE SYNTHESIS; PEPTIDE HYBRIDS; SIGNAL SEQUENCE; LINKED PEPTIDE; BINDING-PROPERTIES; PROTECTING GROUPS; ANTISENSE OLIGONUCLEOTIDES; DESORPTION MASS-SPECTROMETRY; HYBRIDIZATION PROPERTIES

Peptide−DNA hybrids are richly functionalized analogues of biomolecules that may have applications as hybridization probes and antisense agents with tunable binding and targeting properties. So far, synthetic efforts have mainly focused on hybrids bearing a single peptide chain, either at the 5‘- or...