Construction of Quaternary Carbon Center via NHC Catalysis Initiated by an Intermolecular Heck-Type Alkyl Radical Addition

• Published in: Organic letters Vol. 23; no. 12; pp. 4662 - 4666
• Main Authors: Su, Lanjun, Sun, Huan, Liu, Jikai, Wang, Chengming
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 18.06.2021; Amer Chemical Soc
• Subjects: carbon; catalytic activity; cations; Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; REACTIVITY; OXINDOLES; BUTOXIDE; HETEROCYCLES; C-H

A quaternary carbon center containing an oxindole motif is constructed via NHC-catalyzed transition-metal and aldehyde-free intermolecular Heck-type alkyl radical addition initiated annulation. This redox-neutral protocol also features a simple procedure, broad substrate scope, good functional group...