Novel Elements of the Chondrocyte Stress Response Identified Using an in Vitro Model of Mouse Cartilage Degradation

• Published in: Journal of proteome research Vol. 15; no. 3; pp. 1033 - 1050
• Main Authors: Wilson, Richard, Golub, Suzanne B, Rowley, Lynn, Angelucci, Constanza, Karpievitch, Yuliya V, Bateman, John F, Fosang, Amanda J
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 04.03.2016
• Subjects: Animals; Cartilage, Articular - metabolism; Cartilage, Articular - pathology; Cells, Cultured; Chondrocytes - metabolism; Interleukin-1alpha - physiology; Mice, Inbred C57BL; Proteome - metabolism; Stress, Physiological; chondrocyte; osteoarthritis; quantitative proteomics; oxidative stress; cartilage

The destruction of articular cartilage in osteoarthritis involves chondrocyte dysfunction and imbalanced extracellular matrix (ECM) homeostasis. Pro-inflammatory cytokines such as interleukin-1α (IL-1α) contribute to osteoarthritis pathophysiology, but the effects of IL-1α on chondrocytes within the...