Antisolvent Crystallization of Erythromycin Ethylsuccinate in the Presence of Liquid–Liquid Phase Separation

• Published in: Industrial & engineering chemistry research Vol. 55; no. 3; pp. 766 - 776
• Main Authors: Li, Xiang, Yin, Qiuxiang, Zhang, Meijin, Hou, Baohong, Bao, Ying, Gong, Junbo, Hao, Hongxun, Wang, Yongli, Wang, Jingkang, Wang, Zhao
• Format: Journal Article
• Language: English
• Published: American Chemical Society 27.01.2016
• Subjects: crystallization; energy; engineering; erythromycin; monitoring; reflectance; separation; solubility; surface tension; thermodynamics

The nucleation point of erythromycin ethylsuccinate crystallization with liquid–liquid phase separation, also called oiling-out, was determined through nucleation analysis. To achieve successful monitoring of nucleation events, focused beam reflectance measurements were performed during antisolvent...