Synthesis of Polyazamacrocyclic Compounds via Modified Richman−Atkins Cyclization of β-Trimethylsilylethanesulfonamides

• Published in: Journal of organic chemistry Vol. 66; no. 8; pp. 2722 - 2725
• Main Authors: Hoye, Rebecca C, Richman, Jack E, Dantas, Gautam A, Lightbourne, Marissa F, Shinneman, L. Scott
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 20.04.2001; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; AZAPARACYCLOPHANES; ETHERS; PROTECTION; AMINES; CRYSTAL-STRUCTURE; FLUORESCENCE EMISSION; COMPLEXES; CHEMISTRY

The Richman−Atkins cyclization remains one of the most widely used methods for the preparation of macrocyclic polyamines. The use of β-trimethylsilylethanesulfonamides (SES-sulfonamides) for the preparation of polyazamacrocyclic compounds is described. This expands existing Richman−Atkins sulfonamid...