Snake Venomics of the Central American Rattlesnake Crotalus simus and the South American Crotalus durissus Complex Points to Neurotoxicity as an Adaptive Paedomorphic Trend along Crotalus Dispersal in South America

• Published in: Journal of proteome research Vol. 9; no. 1; pp. 528 - 544
• Main Authors: Calvete, Juan J, Sanz, Libia, Cid, Pedro, de la Torre, Pilar, Flores-Díaz, Marietta, Dos Santos, M. Cristina, Borges, Adolfo, Bremo, Adolfo, Angulo, Yamileth, Lomonte, Bruno, Alape-Girón, Alberto, Gutiérrez, José María
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 04.01.2010
• Subjects: Age Factors; Amino Acid Sequence; Animals; Antivenins - metabolism; Crotalid Venoms - chemistry; Crotalid Venoms - genetics; Crotalid Venoms - metabolism; Crotalus - genetics; Crotalus - metabolism; Evolution, Molecular; Molecular Sequence Data; Neurotoxins - genetics; Neurotoxins - metabolism; Proteome; Reptilian Proteins - chemistry; Reptilian Proteins - genetics; Reptilian Proteins - metabolism; South America; Spectrometry, Mass, Electrospray Ionization; South America; Crotalus durissus; antibothropic and anticrotalic ABC antivenom; snake venom protein families; Crotalus simus; polyvalent (Crotalinae) ICP antivenom; crotoxin; paedomorphism; snake venomics; ontogenetic shift; antivenomics

We report a comparative venomic and antivenomic characterization of the venoms of newborn and adult specimens of the Central American rattlesnake, Crotalus simus, and of the subspecies cumanensis, durissus, ruruima, and terrificus of South American Crotalus durissus. Neonate and adult C. simus share...