Bifunctional N‑Heterocyclic Carbenes Derived from l‑Pyroglutamic Acid and Their Applications in Enantioselective Organocatalysis

• Published in: Accounts of chemical research Vol. 53; no. 3; pp. 690 - 702
• Main Authors: Chen, Xiang-Yu, Gao, Zhong-Hua, Ye, Song
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 17.03.2020
• Subjects: Catalysis; Heterocyclic Compounds - chemistry; Methane - analogs & derivatives; Methane - chemistry; Organic Chemicals - chemistry; Pyrrolidonecarboxylic Acid - chemistry; Stereoisomerism

Conspectus In nature, enzymes are a powerful medium for the construction of enantiomerically pure chemicals, which always inspires synthetic chemists to explore new catalysts to imitate the enzyme machinery for asymmetric transformations. Vitamin B1, a bifunctional thiazolium N-heterocyclic carbene...