Discovery of Novel N‑Heterocyclic-Fused Deoxypodophyllotoxin Analogues as Tubulin Polymerization Inhibitors Targeting the Colchicine-Binding Site for Cancer Treatment - Leng, Jiafu; Zhao, Yongjun; Sheng, Ping; Xia, Yuanzheng; Chen, Tingting; Zhao, Shifang; Xie, Shanshan; Yan, Xiangyu; Wang, Xiaobing; Yin, Yong; Kong, Lingyi (Journal of medicinal chemistry, 2022)
Keywords: Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Binding Sites; Cell Line, Tumor; Cell Proliferation; Colchicine - metabolism; Drug Screening Assays, Antitumor; Endothelial Cells - metabolism; Humans; MCF-7 Cells; Neoplasms - drug therapy; Polymerization; Structure-Activity Relationship; Tubulin - metabolism; Tubulin Modulators - chemistry; Tubulin Modulators - pharmacology; Tubulin Modulators - therapeutic use