Ultrasensitive Nanosensors Based on Upconversion Nanoparticles for Selective Hypoxia Imaging in Vivo upon Near-Infrared Excitation

• Published in: Journal of the American Chemical Society Vol. 136; no. 27; pp. 9701 - 9709
• Main Authors: Liu, Jianan, Liu, Yong, Bu, Wenbo, Bu, Jiwen, Sun, Yong, Du, Jiulin, Shi, Jianlin
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 09.07.2014
• Subjects: absorption; Adsorption; anaerobic conditions; Animals; Cell Line, Tumor; Danio rerio; Humans; Hypoxia; image analysis; luminescence; metastasis; Microscopy, Confocal; Molecular Structure; nanoparticles; Nanoparticles - chemistry; Nanotechnology - instrumentation; neoplasms; Organometallic Compounds - chemical synthesis; Organometallic Compounds - chemistry; oxygen; Oxygen - analysis; Particle Size; radiotherapy; Ruthenium - chemistry; Surface Properties; wavelengths; Zebrafish

Hypoxia is a distinct feature of malignant solid tumors, which is a possible causative factor for the serious resistance to chemo- and radiotherapy or the development of invasion and metastasis. The exploration of nanosensors with the capabilities like the accurate diagnosis of hypoxic level will be...