Multitargeted Opioid Ligand Discovery as a Strategy to Retain Analgesia and Reduce Opioid-Related Adverse Effects

• Published in: Journal of medicinal chemistry Vol. 66; no. 6; pp. 3746 - 3784
• Main Authors: Smith, Maree T., Kong, Dehui, Kuo, Andy, Imam, Mohammad Z., Williams, Craig M.
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 23.03.2023
• Subjects: Analgesia; Analgesics, Opioid - adverse effects; Animals; Ligands; Morphine; Pain - drug therapy; Receptors, Opioid, delta; Receptors, Opioid, mu

The global “opioid crisis” has placed enormous pressure on the opioid ligand discovery community to produce novel opioid analgesics with superior opioid-related adverse-effect profiles compared with morphine. In this Perspective, the multitargeted opioid ligand strategy for the discovery of opioid a...