pH-Responsive Nanoparticles Shelled with Chitosan for Oral Delivery of Insulin: From Mechanism to Therapeutic Applications

• Published in: Accounts of chemical research Vol. 45; no. 4; pp. 619 - 629
• Main Authors: Sung, Hsing-Wen, Sonaje, Kiran, Liao, Zi-Xian, Hsu, Li-Wen, Chuang, Er-Yuan
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 17.04.2012
• Subjects: Administration, Oral; Animals; Chitosan; Chitosan - adverse effects; Chitosan - chemistry; Chitosan - pharmacokinetics; Degradation; Drug Carriers - adverse effects; Drug Carriers - chemistry; Drug Carriers - pharmacokinetics; Drugs; Humans; Hydrogen-Ion Concentration; Insulin; Insulin - administration & dosage; Insulin - metabolism; Insulin - pharmacology; Insulin - therapeutic use; Intestines; Nanoparticles; Nanoparticles - chemistry; Proteins

Despite advances in drug-delivery technologies, successful oral administration of protein drugs remains an elusive challenge. When protein drugs are administered orally, they can rapidly denature or degrade before they reach their targets. Such drugs also may not absorb adequately within the small i...