Antiparasitic Activity of Two Natural Terpenes from Salvia cuspidata against Leishmania amazonensis
Leishmaniasis is a neglected disease caused by flagellated parasites of the Leishmania genus affecting more than 10 million people worldwide. Current treatments for leishmaniasis involve the administration of poorly tolerated drugs with toxic side effects in patients. There is an imperative necessit...
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Published in | Journal of natural products (Washington, D.C.) Vol. 86; no. 4; pp. 797 - 803 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Chemical Society and American Society of Pharmacognosy
28.04.2023
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Abstract | Leishmaniasis is a neglected disease caused by flagellated parasites of the Leishmania genus affecting more than 10 million people worldwide. Current treatments for leishmaniasis involve the administration of poorly tolerated drugs with toxic side effects in patients. There is an imperative necessity for novel compounds to treat this disease. One of the most used strategies in the search for different antiparasitic compounds is the screening of purified plant molecules. The diterpenes 12-hydroxy-11,14-diketo-6,8,12-abietatrien-19,20-olide (HABTO) and 5-epi-icetexone (ICTX) isolated from Salvia cuspidata were shown to be effective against Leishmania amazonensis in vitro and in vivo. They displayed an antiproliferative effect against L. amazonensis promastigotes. They also induce an increase in ROS levels and affect the mitochondrial activity of parasites. HABTO and ICTX in an in vivo model of cutaneous leishmaniasis decrease footpad swelling, parasite load, and splenic index. Moreover, they induce significant reduction in the O.D. of total anti-Leishmania IgG and IgG1 subtype antibody responses against L. amazonensis compared to the PBS group but maintain high levels of IgG2a. This suggests that in HABTO- or ICTX-treated mice, there is a slowdown in the progression of the disease. These terpenes could be considered as possible novel antileishmanial agents against L. amazonensis and thus treat cutaneous leishmaniasis. |
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AbstractList | Leishmaniasis is a neglected disease caused by flagellated parasites of the Leishmania genus affecting more than 10 million people worldwide. Current treatments for leishmaniasis involve the administration of poorly tolerated drugs with toxic side effects in patients. There is an imperative necessity for novel compounds to treat this disease. One of the most used strategies in the search for different antiparasitic compounds is the screening of purified plant molecules. The diterpenes 12-hydroxy-11,14-diketo-6,8,12-abietatrien-19,20-olide (HABTO) and 5-epi-icetexone (ICTX) isolated from Salvia cuspidata were shown to be effective against Leishmania amazonensis in vitro and in vivo. They displayed an antiproliferative effect against L. amazonensis promastigotes. They also induce an increase in ROS levels and affect the mitochondrial activity of parasites. HABTO and ICTX in an in vivo model of cutaneous leishmaniasis decrease footpad swelling, parasite load, and splenic index. Moreover, they induce significant reduction in the O.D. of total anti-Leishmania IgG and IgG1 subtype antibody responses against L. amazonensis compared to the PBS group but maintain high levels of IgG2a. This suggests that in HABTO- or ICTX-treated mice, there is a slowdown in the progression of the disease. These terpenes could be considered as possible novel antileishmanial agents against L. amazonensis and thus treat cutaneous leishmaniasis. Leishmaniasis is a neglected disease caused by flagellated parasites of the genus affecting more than 10 million people worldwide. Current treatments for leishmaniasis involve the administration of poorly tolerated drugs with toxic side effects in patients. There is an imperative necessity for novel compounds to treat this disease. One of the most used strategies in the search for different antiparasitic compounds is the screening of purified plant molecules. The diterpenes 12-hydroxy-11,14-diketo-6,8,12-abietatrien-19,20-olide (HABTO) and 5-epi-icetexone (ICTX) isolated from were shown to be effective against and . They displayed an antiproliferative effect against promastigotes. They also induce an increase in ROS levels and affect the mitochondrial activity of parasites. HABTO and ICTX in an model of cutaneous leishmaniasis decrease footpad swelling, parasite load, and splenic index. Moreover, they induce significant reduction in the O.D. of total anti-Leishmania IgG and IgG1 subtype antibody responses against compared to the PBS group but maintain high levels of IgG2a. This suggests that in HABTO- or ICTX-treated mice, there is a slowdown in the progression of the disease. These terpenes could be considered as possible novel antileishmanial agents against and thus treat cutaneous leishmaniasis. |
Author | García Bustos, María Fernanda Cargnelutti, Diego E. Troncoso, Mariana Elizabeth Germanó, María José Cifuente, Diego Lozano, Esteban S. Arrieta, Victoria J. |
AuthorAffiliation | Universidad Nacional de Cuyo Instituto de Investigación en Tecnología Química Consejo Nacional de Investigaciones Científicas y Técnicas Universidad de Mendoza Instituto de Patología Experimental Facultad de Ciencias Exactas y Naturales Instituto de Medicina y Biología Experimental de Cuyo Facultad de Ciencias Médicas |
AuthorAffiliation_xml | – name: Universidad Nacional de Cuyo – name: Instituto de Investigación en Tecnología Química – name: Universidad de Mendoza – name: Instituto de Medicina y Biología Experimental de Cuyo – name: Consejo Nacional de Investigaciones Científicas y Técnicas – name: Instituto de Patología Experimental – name: Facultad de Ciencias Exactas y Naturales – name: Facultad de Ciencias Médicas |
Author_xml | – sequence: 1 givenname: Mariana Elizabeth surname: Troncoso fullname: Troncoso, Mariana Elizabeth organization: Universidad de Mendoza – sequence: 2 givenname: María José orcidid: 0000-0002-4845-1738 surname: Germanó fullname: Germanó, María José organization: Instituto de Medicina y Biología Experimental de Cuyo – sequence: 3 givenname: Victoria J. surname: Arrieta fullname: Arrieta, Victoria J. organization: Instituto de Medicina y Biología Experimental de Cuyo – sequence: 4 givenname: María Fernanda surname: García Bustos fullname: García Bustos, María Fernanda organization: Instituto de Patología Experimental – sequence: 5 givenname: Diego surname: Cifuente fullname: Cifuente, Diego organization: Instituto de Investigación en Tecnología Química – sequence: 6 givenname: Diego E. surname: Cargnelutti fullname: Cargnelutti, Diego E. organization: Universidad Nacional de Cuyo – sequence: 7 givenname: Esteban S. orcidid: 0000-0002-9229-2439 surname: Lozano fullname: Lozano, Esteban S. email: elozano@mendoza-conicet.gob.ar organization: Universidad Nacional de Cuyo |
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Snippet | Leishmaniasis is a neglected disease caused by flagellated parasites of the Leishmania genus affecting more than 10 million people worldwide. Current... Leishmaniasis is a neglected disease caused by flagellated parasites of the genus affecting more than 10 million people worldwide. Current treatments for... |
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SubjectTerms | Animals Antiparasitic Agents - pharmacology Antiprotozoal Agents - pharmacology Antiprotozoal Agents - therapeutic use Leishmania Leishmania mexicana Leishmaniasis, Cutaneous - drug therapy Mice Mice, Inbred BALB C Salvia Terpenes - pharmacology |
Title | Antiparasitic Activity of Two Natural Terpenes from Salvia cuspidata against Leishmania amazonensis |
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