Aminophenol-Decorated Gold Nanoparticles for Curing Bacterial Infections

Nanomaterials usually kill bacteria via multiple mechanisms which are not explicit to the same degree as those of conventional antibiotics. This situation may hinder the development of novel nanoscale antibiotics. Here, we present aminophenol (AP) to modify gold nanoparticles (AP_Au NPs) which show...

Full description

Saved in:
Bibliographic Details
Published inNano letters Vol. 22; no. 9; pp. 3576 - 3582
Main Authors Wang, Le, Zheng, Wenfu, Li, Sixiang, Zhong, Leni, Jiang, Xingyu
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 11.05.2022
Subjects
multidrug-resistant bacteria
16S rRNA
aminoglycosides
gold nanoparticles
antibacterial therapy
Online AccessGet full text

Cover

Abstract Nanomaterials usually kill bacteria via multiple mechanisms which are not explicit to the same degree as those of conventional antibiotics. This situation may hinder the development of novel nanoscale antibiotics. Here, we present aminophenol (AP) to modify gold nanoparticles (AP_Au NPs) which show a broad antibacterial spectrum and potent antibacterial effects against multidrug-resistant (MDR) bacteria with clear antibacterial mechanisms. AP_Au NPs can not only damage bacterial cell walls but also bind to the 16S rRNA to block bacterial protein synthesis. Moreover, AP_Au NPs show excellent performance in curing abdominal bacterial infections in an in vivo model. AP_Au NPs thus have the potential to become a novel antibacterial agent for clinical applications.
AbstractList Nanomaterials usually kill bacteria via multiple mechanisms which are not explicit to the same degree as those of conventional antibiotics. This situation may hinder the development of novel nanoscale antibiotics. Here, we present aminophenol (AP) to modify gold nanoparticles (AP_Au NPs) which show a broad antibacterial spectrum and potent antibacterial effects against multidrug-resistant (MDR) bacteria with clear antibacterial mechanisms. AP_Au NPs can not only damage bacterial cell walls but also bind to the 16S rRNA to block bacterial protein synthesis. Moreover, AP_Au NPs show excellent performance in curing abdominal bacterial infections in an model. AP_Au NPs thus have the potential to become a novel antibacterial agent for clinical applications.
Nanomaterials usually kill bacteria via multiple mechanisms which are not explicit to the same degree as those of conventional antibiotics. This situation may hinder the development of novel nanoscale antibiotics. Here, we present aminophenol (AP) to modify gold nanoparticles (AP_Au NPs) which show a broad antibacterial spectrum and potent antibacterial effects against multidrug-resistant (MDR) bacteria with clear antibacterial mechanisms. AP_Au NPs can not only damage bacterial cell walls but also bind to the 16S rRNA to block bacterial protein synthesis. Moreover, AP_Au NPs show excellent performance in curing abdominal bacterial infections in an in vivo model. AP_Au NPs thus have the potential to become a novel antibacterial agent for clinical applications.Nanomaterials usually kill bacteria via multiple mechanisms which are not explicit to the same degree as those of conventional antibiotics. This situation may hinder the development of novel nanoscale antibiotics. Here, we present aminophenol (AP) to modify gold nanoparticles (AP_Au NPs) which show a broad antibacterial spectrum and potent antibacterial effects against multidrug-resistant (MDR) bacteria with clear antibacterial mechanisms. AP_Au NPs can not only damage bacterial cell walls but also bind to the 16S rRNA to block bacterial protein synthesis. Moreover, AP_Au NPs show excellent performance in curing abdominal bacterial infections in an in vivo model. AP_Au NPs thus have the potential to become a novel antibacterial agent for clinical applications.
Nanomaterials usually kill bacteria via multiple mechanisms which are not explicit to the same degree as those of conventional antibiotics. This situation may hinder the development of novel nanoscale antibiotics. Here, we present aminophenol (AP) to modify gold nanoparticles (AP_Au NPs) which show a broad antibacterial spectrum and potent antibacterial effects against multidrug-resistant (MDR) bacteria with clear antibacterial mechanisms. AP_Au NPs can not only damage bacterial cell walls but also bind to the 16S rRNA to block bacterial protein synthesis. Moreover, AP_Au NPs show excellent performance in curing abdominal bacterial infections in an in vivo model. AP_Au NPs thus have the potential to become a novel antibacterial agent for clinical applications.
Author Li, Sixiang
Jiang, Xingyu
Zhong, Leni
Zheng, Wenfu
Wang, Le
AuthorAffiliation Southern University of Science and Technology
GBA Research Innovation Institute for Nanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety
Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering
National Center for NanoScience and Technology
AuthorAffiliation_xml – name: National Center for NanoScience and Technology
– name: GBA Research Innovation Institute for Nanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety
– name: Southern University of Science and Technology
– name: Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering
Author_xml – sequence: 1
  givenname: Le
  surname: Wang
  fullname: Wang, Le
  organization: Southern University of Science and Technology
– sequence: 2
  givenname: Wenfu
  orcidid: 0000-0003-4671-0000
  surname: Zheng
  fullname: Zheng, Wenfu
  organization: National Center for NanoScience and Technology
– sequence: 3
  givenname: Sixiang
  surname: Li
  fullname: Li, Sixiang
  organization: Southern University of Science and Technology
– sequence: 4
  givenname: Leni
  surname: Zhong
  fullname: Zhong, Leni
  organization: Southern University of Science and Technology
– sequence: 5
  givenname: Xingyu
  orcidid: 0000-0002-5008-4703
  surname: Jiang
  fullname: Jiang, Xingyu
  email: jiang@sustech.edu.cn
  organization: Southern University of Science and Technology
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35486905$$D View this record in MEDLINE/PubMed
BookMark eNqFkL1OwzAURi1UBLTwBghlZEm5ju00Zivlp0gIFpgjx7kBo8QOtjPw9qRqYWCAyZZ8zif5TMnEOouEnFKYU8johdJhbpV1LcY4pxq4zIs9ckQFgzSXMpv83At-SKYhvAOAZAIOyCETvMgliCOyXnbGuv4Nx6H0GrXzKmKd3Lm2Th7H9V75aHSLIWmcT1aDN_Y1uVI6ojeqTe5tgzoaZ8Mx2W9UG_Bkd87Iy-3N82qdPjzd3a-WD6livIipBJ7XlFWIFGrJFhyk1lVW5Sg554JJWTVCLABBNVWWI6XIGkRZCN3AotZsRs63u713HwOGWHYmaGxbZdENocxyUWQsk0KM6NkOHaoO67L3plP-s_z-_QjwLaC9C8Fj84NQKDeRyzFy-R253EUetctfmjZRbSpEr0z7nwxbefP67gZvx1p_K19h2Jfo
CitedBy_id crossref_primary_10_1039_D3DT00889D
crossref_primary_10_3390_biomedicines11020413
crossref_primary_10_1002_smll_202312046
crossref_primary_10_1021_acsabm_3c00265
crossref_primary_10_1021_acsabm_4c00237
crossref_primary_10_1039_D2CC04084K
crossref_primary_10_1039_D2MA00572G
crossref_primary_10_1016_j_surfin_2024_105707
crossref_primary_10_2147_IJN_S394666
crossref_primary_10_1016_j_ifset_2024_103777
crossref_primary_10_1016_j_jece_2024_114779
crossref_primary_10_1016_j_drup_2024_101102
crossref_primary_10_1016_j_colsurfb_2024_114415
crossref_primary_10_1016_j_ijbiomac_2024_129300
crossref_primary_10_1021_acsanm_3c05981
crossref_primary_10_1021_acsomega_3c04893
crossref_primary_10_2147_IJN_S502139
crossref_primary_10_1002_advs_202306070
crossref_primary_10_1002_adhm_202302480
crossref_primary_10_1016_j_bmt_2022_11_010
crossref_primary_10_3390_antibiotics12020398
crossref_primary_10_1021_acsmaterialslett_3c01326
crossref_primary_10_1021_acsnano_3c02886
crossref_primary_10_1016_j_ijpharm_2025_125437
crossref_primary_10_3390_ijms231911348
crossref_primary_10_1007_s00216_022_04402_y
crossref_primary_10_1128_msphere_00549_22
crossref_primary_10_1007_s42765_023_00280_w
crossref_primary_10_1186_s12951_023_02149_x
crossref_primary_10_1021_acsami_2c13166
crossref_primary_10_1039_D3NA00530E
crossref_primary_10_1128_aac_00262_23
crossref_primary_10_1021_acsnano_2c02269
crossref_primary_10_1002_smll_202305988
Cites_doi 10.1021/acsami.9b19712
10.1021/acsnano.1c06139
10.1128/AAC.44.12.3249-3256.2000
10.1002/cbic.201900508
10.1021/nn301714n
10.1021/ja1028843
10.1038/msb.2013.31
10.1534/g3.120.401201
10.1039/c3nr01990j
10.1021/nl034376x
10.1021/acsnano.7b00343
10.1021/ja065864k
10.1016/j.biomaterials.2007.08.036
10.1016/j.biomaterials.2016.06.015
10.1002/adfm.201808594
10.1021/acs.nanolett.0c04451
10.1021/nn507168x
10.1021/acsnano.7b01240
10.1016/j.biomaterials.2011.11.057
10.1038/s41467-017-02502-3
10.1016/j.biomaterials.2012.10.069
10.1038/nm1145
10.1016/j.ejmech.2012.01.006
10.1086/595011
10.1093/nar/gku307
10.1016/j.gene.2016.02.003
10.1021/acs.nanolett.0c04578
ContentType Journal Article
Copyright 2022 American Chemical Society
Copyright_xml – notice: 2022 American Chemical Society
DBID AAYXX
CITATION
NPM
7X8
DOI 10.1021/acs.nanolett.1c04968
DatabaseName CrossRef
PubMed
MEDLINE - Academic
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
DatabaseTitleList PubMed
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Engineering
EISSN 1530-6992
EndPage 3582
ExternalDocumentID 35486905
10_1021_acs_nanolett_1c04968
a990448537
Genre Journal Article
GroupedDBID -
123
4.4
55A
5VS
7~N
AABXI
ABFRP
ABMVS
ABPTK
ABUCX
ACGFS
ACS
AEESW
AENEX
AFEFF
AHGAQ
ALMA_UNASSIGNED_HOLDINGS
AQSVZ
BAANH
CS3
DU5
EBS
ED
F5P
GGK
GNL
IH9
IHE
JG
K2
PK8
RNS
ROL
TN5
UI2
VF5
VG9
W1F
X
---
-~X
.K2
6P2
AAHBH
AAYXX
ABBLG
ABJNI
ABLBI
ABQRX
ACBEA
ADHLV
CITATION
CUPRZ
ED~
JG~
NPM
7X8
ID FETCH-LOGICAL-a348t-9046d13bee10d937409ccb2b6e94445399bf5570e0afb26e11e3fee985cf07dc3
IEDL.DBID ACS
ISSN 1530-6984
1530-6992
IngestDate Thu Jul 10 22:13:36 EDT 2025
Mon Jul 21 06:08:42 EDT 2025
Thu Apr 24 23:11:30 EDT 2025
Tue Jul 01 04:10:01 EDT 2025
Fri May 13 03:17:30 EDT 2022
IsPeerReviewed true
IsScholarly true
Issue 9
Keywords multidrug-resistant bacteria
16S rRNA
aminoglycosides
gold nanoparticles
antibacterial therapy
Language English
License https://doi.org/10.15223/policy-029
https://doi.org/10.15223/policy-037
https://doi.org/10.15223/policy-045
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-a348t-9046d13bee10d937409ccb2b6e94445399bf5570e0afb26e11e3fee985cf07dc3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0003-4671-0000
0000-0002-5008-4703
PMID 35486905
PQID 2658232955
PQPubID 23479
PageCount 7
ParticipantIDs proquest_miscellaneous_2658232955
pubmed_primary_35486905
crossref_primary_10_1021_acs_nanolett_1c04968
crossref_citationtrail_10_1021_acs_nanolett_1c04968
acs_journals_10_1021_acs_nanolett_1c04968
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 20220511
2022-05-11
2022-May-11
PublicationDateYYYYMMDD 2022-05-11
PublicationDate_xml – month: 05
  year: 2022
  text: 20220511
  day: 11
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Nano letters
PublicationTitleAlternate Nano Lett
PublicationYear 2022
Publisher American Chemical Society
Publisher_xml – name: American Chemical Society
References ref9/cit9
ref6/cit6
ref3/cit3
ref27/cit27
ref18/cit18
ref11/cit11
ref25/cit25
ref16/cit16
ref23/cit23
ref14/cit14
ref8/cit8
ref5/cit5
ref2/cit2
ref20/cit20
ref17/cit17
ref10/cit10
ref26/cit26
ref19/cit19
ref21/cit21
ref12/cit12
ref15/cit15
ref22/cit22
ref13/cit13
ref4/cit4
ref1/cit1
ref24/cit24
ref7/cit7
References_xml – ident: ref3/cit3
  doi: 10.1021/acsami.9b19712
– ident: ref11/cit11
  doi: 10.1021/acsnano.1c06139
– ident: ref25/cit25
  doi: 10.1128/AAC.44.12.3249-3256.2000
– ident: ref6/cit6
  doi: 10.1002/cbic.201900508
– ident: ref16/cit16
  doi: 10.1021/nn301714n
– ident: ref20/cit20
  doi: 10.1021/ja1028843
– ident: ref26/cit26
  doi: 10.1038/msb.2013.31
– ident: ref9/cit9
  doi: 10.1534/g3.120.401201
– ident: ref19/cit19
  doi: 10.1039/c3nr01990j
– ident: ref17/cit17
  doi: 10.1021/nl034376x
– ident: ref10/cit10
  doi: 10.1021/acsnano.7b00343
– ident: ref24/cit24
  doi: 10.1021/ja065864k
– ident: ref12/cit12
  doi: 10.1016/j.biomaterials.2007.08.036
– ident: ref18/cit18
  doi: 10.1016/j.biomaterials.2016.06.015
– ident: ref13/cit13
  doi: 10.1002/adfm.201808594
– ident: ref1/cit1
  doi: 10.1021/acs.nanolett.0c04451
– ident: ref8/cit8
  doi: 10.1021/nn507168x
– ident: ref22/cit22
  doi: 10.1021/acsnano.7b01240
– ident: ref4/cit4
  doi: 10.1016/j.biomaterials.2011.11.057
– ident: ref14/cit14
  doi: 10.1038/s41467-017-02502-3
– ident: ref15/cit15
  doi: 10.1016/j.biomaterials.2012.10.069
– ident: ref2/cit2
  doi: 10.1038/nm1145
– ident: ref23/cit23
  doi: 10.1016/j.ejmech.2012.01.006
– ident: ref7/cit7
  doi: 10.1086/595011
– ident: ref27/cit27
  doi: 10.1093/nar/gku307
– ident: ref5/cit5
  doi: 10.1016/j.gene.2016.02.003
– ident: ref21/cit21
  doi: 10.1021/acs.nanolett.0c04578
SSID ssj0009350
Score 2.546315
Snippet Nanomaterials usually kill bacteria via multiple mechanisms which are not explicit to the same degree as those of conventional antibiotics. This situation may...
SourceID proquest
pubmed
crossref
acs
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 3576
Title Aminophenol-Decorated Gold Nanoparticles for Curing Bacterial Infections
URI http://dx.doi.org/10.1021/acs.nanolett.1c04968
https://www.ncbi.nlm.nih.gov/pubmed/35486905
https://www.proquest.com/docview/2658232955
Volume 22
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3JTsMwELWgXODAvpRNQeLCwSV2nMXHUigFCThApd4ib5EQJUUkvfD1jLO0LKoKp0iJx5KXybwnzzwjdAoQmQkIpdh3tcRMhxJzj2gcaaKkCEO3rPC-uw96fXY78AdTovjzBJ-Sc6GyVirSEQwjbxEFiDaIFtESDaLQkq1253EqsusVN7KCEwMl4hGrS-Vm9GIDksq-B6QZKLOINt019FDX7JRJJi-tcS5b6uO3hOMfB7KOVivg6bTLnbKBFky6iVa-yBFuoV779Tm1OgNgjS8tLwUgqp3r0VA78BcGel1l0TmAdJ1OUeDoXJRyz9D1TZXXlWbbqN-9eur0cHXTAhYei3LMgSVr4kljiKsBsADpU0pSGRjOGLPitTKxWl3GFYmkgSHEeIkxPPJV4oZaeTuokY5Ss4ccKRUE_TCB71ZOTAiqEsbhEXFf-zRqojOYiLjylCwuDsEpie3LenbianaayKuXJlaVZLm9OWM4xwpPrN5KyY457U_qVY_Bt-yBiUjNaJzFFOAZIE7u-020W26HSY8eUL2Au_7-P8ZzgJaprZ6w4q_kEDXy97E5AkyTy-NiI38CDDvz8w
linkProvider American Chemical Society
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3JTsMwEB0VOAAH9qWsQeLCwSVO7CQ-lkIp64VF3KJ4iYSAFJH0wtczzlIWCSFOkZx45PGSeU_2PAPsI0RmCYZSwl0tCdOhJMKnmkSaKpmEoVtleF9dB4M7dv7AH1rAm1wYbESOlvJyE_9TXYAe2rIsyYboTdGhCoFtEE3AFOIRz3Kubu_mU2vXLy9mxbWMzEhErMmY-8WKjUsq_x6XfgGbZdDpz8P9uLnlWZOnzqiQHfX-Q8nx3_4swFwNQ51uNW8WoWWyJZj9Ik64DIPuy2NmVQewNjm2LBVhqXZOh8_awX8yku36TJ2DuNfplemOzlEl_oymz-pTXlm-Anf9k9vegNT3LpDEZ1FBBHJmTX1pDHU1whekgEpJTwZGMMaslK1MrXKXcZNUeoGh1PipMSLiKnVDrfxVmMyGmVkHR0qFECBM8b0VF0sST6VM4CMSXHMvasMBdkRcr5s8LrfEPRrbwqZ34rp32uA3IxSrWsDc3qPx_EctMq71Wgl4_PH9XjP4Ma40u32SZGY4ymMPwRriT8F5G9aqWTG26CPxC4TLN_7hzy5MD26vLuPLs-uLTZjxbF6FlYWlWzBZvI3MNqKdQu6Uc_sDhEn8VA
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ZS8NAEB48QPTB-6hnBF982JpNNsc-1tZaryKoUHwJ2SMg1lRM-uKvdzZJ6wFF9CmwyQ7ZzUzmG2bnG4AjhMgsRldKPFsJwlQgCHepIqGiUsRBYJcV3jddv_PALnte70urL3yJDCVlRRLfWPWrSiqGAXpixtM4HeCK8jqVCG79cBpmTebOxF2N5t0n365bNGdFe8boiIdsVDU3QYrxTTL77psmAM7C8bSX4HH8ysV5k-f6MBd1-f6DzfFfa1qGxQqOWo1Sf1ZgSqersPCFpHANOo2Xp9SwD-Bs0jLRKsJTZZ0P-srCfzMG3dXZOgvxr9Usyh6t05IEGkVfVKe90mwdHtpn980OqfovkNhlYU44xs6KukJraiuEMRgKSikc4WvOGDOUtiIxDF7ajhPh-JpS7SZa89CTiR0o6W7ATDpI9RZYQkiEAkGC9w3JWBw7MmEcLyH3lOeENTjGjYgq-8miIjXu0MgMjnYnqnanBu7oK0WyIjI3_TT6v8wi41mvJZHHL88fjhQgQoszaZQ41YNhFjkI2hCHcs-rwWapGWOJLgaAPre97T-s5wDmblvt6Pqie7UD844przDssHQXZvK3od5D0JOL_UK9PwCezf7X
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Aminophenol-Decorated+Gold+Nanoparticles+for+Curing+Bacterial+Infections&rft.jtitle=Nano+letters&rft.au=Wang%2C+Le&rft.au=Zheng%2C+Wenfu&rft.au=Li%2C+Sixiang&rft.au=Zhong%2C+Leni&rft.date=2022-05-11&rft.eissn=1530-6992&rft.volume=22&rft.issue=9&rft.spage=3576&rft_id=info:doi/10.1021%2Facs.nanolett.1c04968&rft_id=info%3Apmid%2F35486905&rft.externalDocID=35486905
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1530-6984&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1530-6984&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1530-6984&client=summon