Discovery of Near-Infrared Heptamethine Cyanine Probes for Imaging-Guided Surgery in Solid Tumors

• Published in: Journal of medicinal chemistry Vol. 67; no. 7; pp. 5800 - 5812
• Main Authors: Lin, Qiao, Li, Changsheng, Wang, Yuhua, Zhu, Yanqing, Gu, Yueqing
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 11.04.2024; Amer Chemical Soc
• Subjects: Carcinoma, Hepatocellular; Chemistry, Medicinal; Fluorescent Dyes; Humans; Life Sciences & Biomedicine; Liver Neoplasms; Optical Imaging - methods; Pharmacology & Pharmacy; Science & Technology; Surgery, Computer-Assisted - methods

Near-infrared (NIR) fluorescence imaging has attracted much attention in image-guided interventions with unique advantages. However, the clinical translation rate of fluorescence probes is extremely low, primarily due to weak lesion signal contrast and poor specificity. To address this dilemma, a se...