Structure-Guided Discovery of cis-Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors - Kuhn, Bernd; Ritter, Martin; Hornsperger, Benoit; Bell, Charles; Kocer, Buelent; Rombach, Didier; Lutz, Marius D. R.; Gobbi, Luca; Kuratli, Martin; Bartelmus, Christian; Bürkler, Markus; Koller, Raffael; et al. (Journal of medicinal chemistry, 2024)
Keywords: Animals; Chemistry, Medicinal; Drug Discovery; Enzyme Inhibitors - chemical synthesis; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - pharmacokinetics; Enzyme Inhibitors - pharmacology; Humans; Life Sciences & Biomedicine; Male; Mice; Molecular Structure; Monoacylglycerol Lipases - antagonists & inhibitors; Monoacylglycerol Lipases - metabolism; Oxazines - chemical synthesis; Oxazines - chemistry; Oxazines - pharmacokinetics; Oxazines - pharmacology; Pharmacology & Pharmacy; Pyridines - chemical synthesis; Pyridines - chemistry; Pyridines - pharmacokinetics; Pyridines - pharmacology; Rats; Science & Technology; Structure-Activity Relationship; POTENT; CANNABINOID RECEPTOR; ANANDAMIDE; DEGRADATION; MECHANISMS; BLOCKADE; PROTEINS; DERIVATIVES; AGONIST