Self-Assembled Near-Infrared Dye Nanoparticles as a Selective Protein Sensor by Activation of a Dormant Fluorophore

• Published in: Journal of the American Chemical Society Vol. 136; no. 38; pp. 13233 - 13239
• Main Authors: Anees, Palapuravan, Sreejith, Sivaramapanicker, Ajayaghosh, Ayyappanpillai
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 24.09.2014; Amer Chemical Soc
• Subjects: blood serum; Chemistry; Chemistry, Multidisciplinary; Cyclobutanes - chemistry; diagnostic techniques; fluorescence; fluorescent dyes; Fluorescent Dyes - chemistry; human serum albumin; Humans; Infrared Rays; ions; Models, Molecular; nanoparticles; Nanoparticles - chemistry; Phenols - chemistry; Physical Sciences; Science & Technology; Serum Albumin - analysis; Spectrometry, Fluorescence; Sulfhydryl Compounds - chemistry; thiols; BINDING MECHANISM; AGGREGATION-INDUCED EMISSION; IN-VIVO; EMITTING SQUARAINE DYES; TURN-ON DETECTION; IR DYES; BOVINE SERUM-ALBUMIN; FLUORESCENT-PROBE; AQUEOUS-SOLUTION; LIVING CELLS

Design of selective sensors for a specific analyte in blood serum, which contains a large number of proteins, small molecules, and ions, is important in clinical diagnostics. While metal and polymeric nanoparticle conjugates have been used as sensors, small molecular assemblies have rarely been expl...