Cholesteryl Phosphocholine – A Study on Its Interactions with Ceramides and Other Membrane Lipids

• Published in: Langmuir Vol. 29; no. 7; pp. 2319 - 2329
• Main Authors: Lönnfors, Max, Långvik, Otto, Björkbom, Anders, Slotte, J.Peter
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 19.02.2013
• Subjects: ceramides; Ceramides - chemistry; cholesterol; gels; hydrophobicity; Membrane Lipids - chemistry; Molecular Structure; phosphatidylcholines; Phosphatidylcholines - chemistry; sphingomyelins; synthesis
• ISSN: 0743-7463; 1520-5827; 1520-5827
• DOI: 10.1021/la3051324

We prepared cholesteryl phosphocholine (CholPC) by chemical synthesis and studied its interactions with small (ceramide and cholesterol) and large headgroup (sphingomyelin (SM) and phosphatidylcholine) colipids in bilayer membranes. We established that CholPC could form bilayers (giant uni- and mult...