Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD- scid IL2Rγ null Mouse Model of Malaria

A series of 4-amino 2-anilinoquinazolines optimized for activity against the most lethal malaria parasite of humans, , was evaluated for activity against other human parasites and related apicomplexans that infect humans and animals. Four of the most promising compounds from the 4-amino 2-anilinoqui...

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Published inAntimicrobial agents and chemotherapy Vol. 63; no. 3
Main Authors Gilson, Paul R, Nguyen, William, Poole, William A, Teixeira, Jose E, Thompson, Jennifer K, Guo, Kaiyuan, Stewart, Rebecca J, Ashton, Trent D, White, Karen L, Sanz, Laura M, Gamo, Francisco-Javier, Charman, Susan A, Wittlin, Sergio, Duffy, James, Tonkin, Christopher J, Tham, Wai-Hong, Crabb, Brendan S, Cooke, Brian M, Huston, Christopher D, Cowman, Alan F, Sleebs, Brad E
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.03.2019
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