Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases

• Published in: Journal of medicinal chemistry Vol. 60; no. 4; pp. 1400 - 1416
• Main Authors: Tassini, Sabrina, Sun, Liang, Lanko, Kristina, Crespan, Emmanuele, Langron, Emily, Falchi, Federico, Kissova, Miroslava, Armijos-Rivera, Jorge I, Delang, Leen, Mirabelli, Carmen, Neyts, Johan, Pieroni, Marco, Cavalli, Andrea, Costantino, Gabriele, Maga, Giovanni, Vergani, Paola, Leyssen, Pieter, Radi, Marco
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 23.02.2017; Amer Chemical Soc
• Subjects: Antiviral Agents - chemistry; Antiviral Agents - pharmacology; Chemistry, Medicinal; Cystic Fibrosis - drug therapy; Cystic Fibrosis - genetics; Cystic Fibrosis - virology; Cystic Fibrosis Transmembrane Conductance Regulator - chemistry; Cystic Fibrosis Transmembrane Conductance Regulator - genetics; Drug Discovery; Enterovirus - drug effects; Enterovirus Infections - drug therapy; Enterovirus Infections - genetics; Enterovirus Infections - virology; Humans; Life Sciences & Biomedicine; Models, Molecular; Molecular Docking Simulation; Mutation; Pharmacology & Pharmacy; Protein Folding - drug effects; Science & Technology; Small Molecule Libraries - chemistry; Small Molecule Libraries - pharmacology; PHOSPHATIDYLINOSITOL 4-KINASES; 4-KINASE III-BETA; IN-VITRO; DC-SIGN; DRUG DISCOVERY; ENTEROVIRUS 71; RESPIRATORY VIRAL-INFECTIONS; INHIBITORS; DELTA-F508-CFTR CORRECTORS; CELL REGULATION

Enteroviruses (EVs) are among the most frequent infectious agents in humans worldwide and represent the leading cause of upper respiratory tract infections. No drugs for the treatment of EV infections are currently available. Recent studies have also linked EV infection with pulmonary exacerbations,...