Supramolecular Chemotherapy: Host–Guest Complexes of Heptaplatin-Cucurbit[7]uril toward Colorectal Normal and Tumor Cells
Supramolecular chemotherapy is a strategy that is currently used to improve the therapeutic efficacy of traditional chemotherapy while mitigating side effects. Heptaplatin, a platinum chemotherapeutic antitumor drug in colorectal tumors, is traditionally used in the clinic. However, its side effects...
Saved in:
Published in | Langmuir Vol. 37; no. 18; pp. 5475 - 5482 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Chemical Society
11.05.2021
|
Online Access | Get full text |
Cover
Loading…
Abstract | Supramolecular chemotherapy is a strategy that is currently used to improve the therapeutic efficacy of traditional chemotherapy while mitigating side effects. Heptaplatin, a platinum chemotherapeutic antitumor drug in colorectal tumors, is traditionally used in the clinic. However, its side effects and low efficiency in killing tumors remain unresolved. Herein, a facile supramolecular chemotherapy platform on account of the host–guest chemistry between cucurbit[7]uril and the commercially available heptaplatin was studied. At pH 7.4, heptaplatin showed a strong binding to the cucurbit[7]uril nanocarrier by 1H NMR, whose K a was (1.38 ± 0.06) × 106 M–1 by isothermal titration calorimetry (ITC). At pH 6.0 in a tumor microenvironment, overexpressed spermine can exchange competitively heptaplatin from heptaplatin-CB[7]. This supramolecular complex achieved higher antitumor activity on colorectal tumor cells and lower cytotoxicity than the drug alone on colorectal normal cells. Furthermore, the antitumor mechanisms of supramolecular complex were investigated by apoptosis, cell cycle, and spermine synthase. It was found that heptaplatin-CB[7] consumed more colorectal tumorous intracellular spermine by the spermine synthase assay (413.85 ± 0.004 pg/mL); hepataplatin-CB[7] caused early apoptosis (87.73%) of colorectal tumor cells; heptaplatin-CB[7] induced an inhibitory response in the G1 phase of the tumor cell cycle. These findings demonstrated that heptaplatin-CB[7] had higher antitumor activity toward human colorectal tumor cells but lower cytotoxicity toward human colorectal normal cells. It is expected to promote the supramolecular chemotherapy and translational development of the nanocomplex into the clinical field. |
---|---|
AbstractList | Supramolecular chemotherapy is a strategy that is currently used to improve the therapeutic efficacy of traditional chemotherapy while mitigating side effects. Heptaplatin, a platinum chemotherapeutic antitumor drug in colorectal tumors, is traditionally used in the clinic. However, its side effects and low efficiency in killing tumors remain unresolved. Herein, a facile supramolecular chemotherapy platform on account of the host–guest chemistry between cucurbit[7]uril and the commercially available heptaplatin was studied. At pH 7.4, heptaplatin showed a strong binding to the cucurbit[7]uril nanocarrier by 1H NMR, whose K a was (1.38 ± 0.06) × 106 M–1 by isothermal titration calorimetry (ITC). At pH 6.0 in a tumor microenvironment, overexpressed spermine can exchange competitively heptaplatin from heptaplatin-CB[7]. This supramolecular complex achieved higher antitumor activity on colorectal tumor cells and lower cytotoxicity than the drug alone on colorectal normal cells. Furthermore, the antitumor mechanisms of supramolecular complex were investigated by apoptosis, cell cycle, and spermine synthase. It was found that heptaplatin-CB[7] consumed more colorectal tumorous intracellular spermine by the spermine synthase assay (413.85 ± 0.004 pg/mL); hepataplatin-CB[7] caused early apoptosis (87.73%) of colorectal tumor cells; heptaplatin-CB[7] induced an inhibitory response in the G1 phase of the tumor cell cycle. These findings demonstrated that heptaplatin-CB[7] had higher antitumor activity toward human colorectal tumor cells but lower cytotoxicity toward human colorectal normal cells. It is expected to promote the supramolecular chemotherapy and translational development of the nanocomplex into the clinical field. Supramolecular chemotherapy is a strategy that is currently used to improve the therapeutic efficacy of traditional chemotherapy while mitigating side effects. Heptaplatin, a platinum chemotherapeutic antitumor drug in colorectal tumors, is traditionally used in the clinic. However, its side effects and low efficiency in killing tumors remain unresolved. Herein, a facile supramolecular chemotherapy platform on account of the host-guest chemistry between cucurbit[7]uril and the commercially available heptaplatin was studied. At pH 7.4, heptaplatin showed a strong binding to the cucurbit[7]uril nanocarrier by H NMR, whose was (1.38 ± 0.06) × 10 M by isothermal titration calorimetry (ITC). At pH 6.0 in a tumor microenvironment, overexpressed spermine can exchange competitively heptaplatin from heptaplatin-CB[7]. This supramolecular complex achieved higher antitumor activity on colorectal tumor cells and lower cytotoxicity than the drug alone on colorectal normal cells. Furthermore, the antitumor mechanisms of supramolecular complex were investigated by apoptosis, cell cycle, and spermine synthase. It was found that heptaplatin-CB[7] consumed more colorectal tumorous intracellular spermine by the spermine synthase assay (413.85 ± 0.004 pg/mL); hepataplatin-CB[7] caused early apoptosis (87.73%) of colorectal tumor cells; heptaplatin-CB[7] induced an inhibitory response in the G phase of the tumor cell cycle. These findings demonstrated that heptaplatin-CB[7] had higher antitumor activity toward human colorectal tumor cells but lower cytotoxicity toward human colorectal normal cells. It is expected to promote the supramolecular chemotherapy and translational development of the nanocomplex into the clinical field. |
Author | Liu, Hanrui Huang, Xin Chen, Yueyue Xu, Lixin Jiao, Rong Qin, Changfu Zhou, Hang |
AuthorAffiliation | Department of Hernia and Abdominal Wall Surgery, Beijing Chao-Yang Hospital Beijing Key Laboratory of Environmental Toxicology, Department of Toxicology and Sanitary Chemistry, School of Public Health Capital Medical University Department of Neurosurgery, Xuanwu Hospital |
AuthorAffiliation_xml | – name: Department of Hernia and Abdominal Wall Surgery, Beijing Chao-Yang Hospital – name: Capital Medical University – name: Beijing Key Laboratory of Environmental Toxicology, Department of Toxicology and Sanitary Chemistry, School of Public Health – name: Department of Neurosurgery, Xuanwu Hospital |
Author_xml | – sequence: 1 givenname: Xin surname: Huang fullname: Huang, Xin organization: Beijing Key Laboratory of Environmental Toxicology, Department of Toxicology and Sanitary Chemistry, School of Public Health – sequence: 2 givenname: Hang surname: Zhou fullname: Zhou, Hang organization: Beijing Key Laboratory of Environmental Toxicology, Department of Toxicology and Sanitary Chemistry, School of Public Health – sequence: 3 givenname: Rong surname: Jiao fullname: Jiao, Rong organization: Beijing Key Laboratory of Environmental Toxicology, Department of Toxicology and Sanitary Chemistry, School of Public Health – sequence: 4 givenname: Hanrui surname: Liu fullname: Liu, Hanrui organization: Beijing Key Laboratory of Environmental Toxicology, Department of Toxicology and Sanitary Chemistry, School of Public Health – sequence: 5 givenname: Changfu surname: Qin fullname: Qin, Changfu organization: Department of Hernia and Abdominal Wall Surgery, Beijing Chao-Yang Hospital – sequence: 6 givenname: Lixin surname: Xu fullname: Xu, Lixin organization: Capital Medical University – sequence: 7 givenname: Yueyue orcidid: 0000-0002-3283-0039 surname: Chen fullname: Chen, Yueyue email: ccccc1yy@ccmu.edu.cn organization: Beijing Key Laboratory of Environmental Toxicology, Department of Toxicology and Sanitary Chemistry, School of Public Health |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33913723$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kM1KxDAUhYMozvjzBiJ9gY5Jk7aJOyk6I4gu1JVIySS3Wkmbkh90cOM7-IY-iZVxXLo6m_Ody_320HZve0DoiOAZwRk5kcrPjOyfuti6GVaYFphuoSnJM5zmPCu30RSXjKYlK-gE7Xn_gjEWlIldNKFUEFpmdIreb-PgZGcNqGikS6pn6Gx4BieH1WmysD58fXzOI_iQVLYbDLyBT2yTLGAIcjAytH1aRRXdsg0P5WN0rUmCfZVOj31jHaggTXJtXTeG7HVyFzs7ngFj_AHaaaTxcPib--j-4vyuWqRXN_PL6uwqlZTxkDK-bBgjRAMTTVNiwKzUekm54KXGJMtzKQE0LQRw1SgCIhdcAC6oVpzLgu4jtt5VznrvoKkH13bSrWqC6x-X9eiy3risf12O2PEaG-KyA_0HbeSNBbwu_OAvNrp-_OL_zW9yb4nO |
CitedBy_id | crossref_primary_10_1016_j_matdes_2021_110366 crossref_primary_10_1002_adma_202304249 crossref_primary_10_3390_polym14224855 crossref_primary_10_3390_bios12080633 crossref_primary_10_1021_acs_langmuir_1c01422 crossref_primary_10_1021_acsabm_3c00244 crossref_primary_10_3390_molecules27082466 crossref_primary_10_1002_cbdv_202300061 crossref_primary_10_1007_s43630_022_00174_7 crossref_primary_10_1021_acsanm_2c05391 crossref_primary_10_1021_acs_langmuir_2c02388 |
Cites_doi | 10.1038/s41467-020-19225-7 10.1039/C8CC07858K 10.1016/j.biomaterials.2018.02.051 10.1111/nyas.13376 10.1038/nrm3629 10.3923/pjbs.2010.896.900 10.1002/adma.201806328 10.1016/j.actbio.2016.10.042 10.1002/anie.201707164 10.1016/j.tiv.2019.104679 10.1186/s12935-020-01340-6 10.1039/C6CS00898D 10.5414/cp202023 10.1016/j.envpol.2020.114149 10.1021/acsami.0c03564 10.3390/cells9081775 10.7150/thno.31485 10.1021/acsomega.8b01335 10.1021/acsami.6b08295 10.3390/pharmaceutics12030288 10.1021/acsami.7b01157 10.1021/acsami.9b14075 10.1016/j.biomaterials.2019.119602 10.1039/c0dt00292e 10.3892/ijo.2019.4780 10.1016/j.jconrel.2020.05.008 10.1200/JCO.2016.69.0032 10.1158/0008-5472.CAN-07-6611 10.1007/s00280-016-2976-z 10.1002/cam4.1769 10.1039/C6DT03498E 10.1002/jcp.25801 10.1186/s12935-020-01545-9 10.1021/acsami.7b19784 10.1021/acs.langmuir.9b03325 10.18632/oncotarget.13582 10.1016/j.apsb.2019.10.011 10.1016/j.colsurfb.2020.111195 10.1038/s41467-020-17067-x 10.31635/ccschem.020.202000505 10.1016/j.msec.2019.110152 10.1016/j.trechm.2020.08.008 10.1097/CAD.0000000000000465 10.1016/j.ejmech.2017.12.025 10.1080/15360288.2020.1734144 10.3892/ol.2020.12275 |
ContentType | Journal Article |
Copyright | 2021 American Chemical Society |
Copyright_xml | – notice: 2021 American Chemical Society |
DBID | NPM AAYXX CITATION |
DOI | 10.1021/acs.langmuir.0c03603 |
DatabaseName | PubMed CrossRef |
DatabaseTitle | PubMed CrossRef |
DatabaseTitleList | PubMed |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Chemistry |
EISSN | 1520-5827 |
EndPage | 5482 |
ExternalDocumentID | 10_1021_acs_langmuir_0c03603 33913723 b370380546 |
Genre | Journal Article |
GroupedDBID | - .K2 02 4.4 55A 5GY 5VS 7~N AABXI ABFLS ABFRP ABMVS ABPTK ABUCX ACGFS ACJ ACNCT ACS AEESW AENEX AFEFF AHGAQ ALMA_UNASSIGNED_HOLDINGS AQSVZ BAANH CS3 DU5 EBS ED ED~ F5P GGK GNL IH9 IHE JG JG~ K2 RNS ROL TN5 UI2 UPT VF5 VG9 W1F X --- -~X 53G AAHBH ABJNI ABQRX ADHLV AGXLV CUPRZ NPM YQT ~02 AAYXX CITATION |
ID | FETCH-LOGICAL-a348t-48bf4411de49ff70e047ddb38987d01255aaeed369e8cfc1e95989e063dc88a63 |
IEDL.DBID | ACS |
ISSN | 0743-7463 |
IngestDate | Fri Aug 23 00:50:22 EDT 2024 Sat Sep 28 08:30:33 EDT 2024 Thu May 13 11:05:52 EDT 2021 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 18 |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-a348t-48bf4411de49ff70e047ddb38987d01255aaeed369e8cfc1e95989e063dc88a63 |
ORCID | 0000-0002-3283-0039 |
PMID | 33913723 |
PageCount | 8 |
ParticipantIDs | crossref_primary_10_1021_acs_langmuir_0c03603 pubmed_primary_33913723 acs_journals_10_1021_acs_langmuir_0c03603 |
ProviderPackageCode | JG~ 55A AABXI GNL VF5 7~N ACJ VG9 GGK W1F ABFRP ACS AEESW AFEFF .K2 ABMVS ABUCX IH9 BAANH AQSVZ ED~ UI2 |
PublicationCentury | 2000 |
PublicationDate | 20210511 2021-May-11 2021-05-11 |
PublicationDateYYYYMMDD | 2021-05-11 |
PublicationDate_xml | – month: 05 year: 2021 text: 20210511 day: 11 |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Langmuir |
PublicationTitleAlternate | Langmuir |
PublicationYear | 2021 |
Publisher | American Chemical Society |
Publisher_xml | – name: American Chemical Society |
References | ref9/cit9 ref45/cit45 ref6/cit6 ref36/cit36 ref3/cit3 ref27/cit27 ref18/cit18 ref11/cit11 ref25/cit25 ref16/cit16 ref29/cit29 ref32/cit32 ref23/cit23 ref39/cit39 ref14/cit14 ref8/cit8 ref5/cit5 ref31/cit31 ref2/cit2 ref43/cit43 ref34/cit34 ref37/cit37 ref28/cit28 ref40/cit40 ref20/cit20 ref17/cit17 ref10/cit10 ref26/cit26 ref35/cit35 ref19/cit19 ref21/cit21 ref12/cit12 ref15/cit15 ref42/cit42 ref46/cit46 ref41/cit41 ref22/cit22 ref13/cit13 ref33/cit33 ref4/cit4 ref30/cit30 ref1/cit1 ref24/cit24 ref38/cit38 ref44/cit44 ref7/cit7 |
References_xml | – ident: ref13/cit13 doi: 10.1038/s41467-020-19225-7 – ident: ref40/cit40 doi: 10.1039/C8CC07858K – ident: ref21/cit21 doi: 10.1016/j.biomaterials.2018.02.051 – ident: ref25/cit25 doi: 10.1111/nyas.13376 – ident: ref42/cit42 doi: 10.1038/nrm3629 – ident: ref9/cit9 doi: 10.3923/pjbs.2010.896.900 – ident: ref12/cit12 doi: 10.1002/adma.201806328 – ident: ref34/cit34 doi: 10.1016/j.actbio.2016.10.042 – ident: ref22/cit22 doi: 10.1002/anie.201707164 – ident: ref36/cit36 doi: 10.1016/j.tiv.2019.104679 – ident: ref2/cit2 doi: 10.1186/s12935-020-01340-6 – ident: ref16/cit16 doi: 10.1039/C6CS00898D – ident: ref28/cit28 doi: 10.5414/cp202023 – ident: ref45/cit45 doi: 10.1016/j.envpol.2020.114149 – ident: ref10/cit10 doi: 10.1021/acsami.0c03564 – ident: ref30/cit30 doi: 10.3390/cells9081775 – ident: ref24/cit24 doi: 10.7150/thno.31485 – ident: ref33/cit33 doi: 10.1021/acsomega.8b01335 – ident: ref20/cit20 doi: 10.1021/acsami.6b08295 – ident: ref4/cit4 doi: 10.3390/pharmaceutics12030288 – ident: ref19/cit19 doi: 10.1021/acsami.7b01157 – ident: ref11/cit11 doi: 10.1021/acsami.9b14075 – ident: ref5/cit5 doi: 10.1016/j.biomaterials.2019.119602 – ident: ref7/cit7 doi: 10.1039/c0dt00292e – ident: ref39/cit39 doi: 10.3892/ijo.2019.4780 – ident: ref18/cit18 doi: 10.1016/j.jconrel.2020.05.008 – ident: ref43/cit43 doi: 10.1200/JCO.2016.69.0032 – ident: ref3/cit3 doi: 10.1158/0008-5472.CAN-07-6611 – ident: ref8/cit8 doi: 10.1007/s00280-016-2976-z – ident: ref29/cit29 doi: 10.1002/cam4.1769 – ident: ref32/cit32 doi: 10.1039/C6DT03498E – ident: ref1/cit1 doi: 10.1002/jcp.25801 – ident: ref37/cit37 doi: 10.1186/s12935-020-01545-9 – ident: ref44/cit44 doi: 10.1021/acsami.7b19784 – ident: ref17/cit17 doi: 10.1021/acs.langmuir.9b03325 – ident: ref41/cit41 doi: 10.18632/oncotarget.13582 – ident: ref14/cit14 doi: 10.1016/j.apsb.2019.10.011 – ident: ref15/cit15 doi: 10.1016/j.colsurfb.2020.111195 – ident: ref27/cit27 doi: 10.1038/s41467-020-17067-x – ident: ref23/cit23 doi: 10.31635/ccschem.020.202000505 – ident: ref46/cit46 doi: 10.1016/j.msec.2019.110152 – ident: ref26/cit26 doi: 10.1016/j.trechm.2020.08.008 – ident: ref38/cit38 doi: 10.1097/CAD.0000000000000465 – ident: ref31/cit31 doi: 10.1016/j.ejmech.2017.12.025 – ident: ref6/cit6 doi: 10.1080/15360288.2020.1734144 – ident: ref35/cit35 doi: 10.3892/ol.2020.12275 |
SSID | ssj0009349 |
Score | 2.48307 |
Snippet | Supramolecular chemotherapy is a strategy that is currently used to improve the therapeutic efficacy of traditional chemotherapy while mitigating side effects.... |
SourceID | crossref pubmed acs |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 5475 |
Title | Supramolecular Chemotherapy: Host–Guest Complexes of Heptaplatin-Cucurbit[7]uril toward Colorectal Normal and Tumor Cells |
URI | http://dx.doi.org/10.1021/acs.langmuir.0c03603 https://www.ncbi.nlm.nih.gov/pubmed/33913723 |
Volume | 37 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LT9wwELYQPdALLe8tD_nQSw9eHNtxEm5oBV0hAQdAQkIoih-RVmSTVR5SC5f-h_7D_pJ6NgmIIlS4JiNPNHbm-2zPA6Gv0lLLqWaEq4AREYWWKCo1kcpEjPom1QzynU_P5PhKnFz7108bxX9v8Jm3n-hqCGd302ZSDql2HheKe35gDhphs3U4ungqsstbugtlNwMheZ8q98ooAEi6egZIz6jlHGKOP6HzPlGnjSy5Gza1Gur7l3Ub3_j1n9FyxzbxYbs8VtCCzVfR0qhv8raGHi6aWZlM-x65GF51OVk_D_C4qOo_v35_B-jA4Dky-8NWuEjx2M7qZAZxdDkZNbop1aS-CW6bcpLheh6J6-SzAtyp038GxDjDSW7wZTMtnBqbZdU6ujo-uhyNSdePgSRchDURoUode_KMFXDSSy0VgTHKUZ4wMA7ofD9JHORyGdlQp9qzkR-FkXUkyOgwTCTfQIt5kdsthFMlVEqV4FIr6H-tpNAptYJ53EhPiQH65iwXd_9TFc-vypkXw8PenHFnzgEi_QTGs7ZEx3_kN9tZfpTmPPJ4wPiXd2jdRh8ZhLdAIVdvBy3WZWN3HT-p1d58Uf4FIcPlVQ |
link.rule.ids | 315,786,790,2782,27107,27955,27956,57091,57141 |
linkProvider | American Chemical Society |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3LTtwwFLUQXcCGPqAw0IcXbFh46sSOk7CrRp2mPGbDgJAQiuJHpFEzySgPCdoN_9A_7JfUN5MwolJVsXUs27l-nCP73nMROhSGGkaVS5j0XcLDwBBJhSJC6tClnk6VC_HO5xMRXfKTa-96DXl9LIwdRGVbqtpH_JW6gPMJyuAKb97MyiFV9uAFjc8Xnm8BDxjR6GKltcuWrBfUN30uWB8x949WAJdU9QSXnjDMFmnGL9HV4xhbB5Pvw6aWQ_XjL_nGZ__EK7TVcU_8eblYXqM1k79BG6M-5ds2-nnRLMpk3mfMxfCpi9C6P8ZRUdW_H359BSDBcI5k5s5UuEhxZBZ1sgCvupyMGtWUclbf-LdNOctw3frl2vpZAYer7X8CNDnDSa7xtJkXthuTZdUOuhx_mY4i0mVnIAnjQU14IFPLpRxtONz7UkO5r7W0BCjwtYU9z0sSC8BMhCZQqXJM6IVBaCwl0ioIEsHeovW8yM0ewqnkMqWSM6EkZMOWgquUGu46TAtH8gE6spaLu91Vxe3DuevEUNibM-7MOUCkn8d4sRTs-E_93eVkP9ZmLHSY77L9Z_T6EW1E0_Oz-Ozb5PQAbbrg-AISr847tF6XjXlvmUstP7Tr9A_1AO3A |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LbtQwFLVQKwGbthQoLS8v2LDwYMeOk7Crph0GWkZIbaWKqoriR6QRmSTKQ-Kx4R_4Q76kvpmkUKQKtVvH8nVsX58j-_pchF5JSy2n2iNcBR4RUWiJolITqUzkUd-k2oP3zh9ncnoiPpz6p3-l-nKdqF1LdXeJD15dmrRXGGBvoByO8RbtvBpR7TZf0Plc9QMmwCd3x0d_9Hb5kvmCAmcgJB9ezV3TCmCTrq9g0xWW2aHNZB19vuxnF2TyZdQ2aqS__yPheKsf2UBrPQfFu8tF8wDdsfkmujceUr89RD-O2rJKFkPmXAyf-pda397iaVE3v3_-egeAgmE_yexXW-MixVNbNkkJ0XU5Gbe6rdS8OQvO22qe4aaLz3X1swI2WWd_BnQ5w0lu8HG7KJwZm2X1I3Qy2T8eT0mfpYEkXIQNEaFKHadixgo4_6WWisAY5YhQGBgHf76fJA6IuYxsqFPNbORHYWQdNTI6DBPJH6OVvMjtE4RTJVRKleBSK8iKraTQKbXCY9xIpsQ2eu1GLu69rI67C3SPxVA4DGfcD-c2IsNcxuVSuOM_9beWE35Zm_OI8cDjOzew-hLd_bQ3iQ_fzw6eovsexL-A0it7hlaaqrXPHYFp1ItuqV4AdezwOg |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Supramolecular+Chemotherapy%3A+Host%E2%80%93Guest+Complexes+of+Heptaplatin-Cucurbit%5B7%5Duril+toward+Colorectal+Normal+and+Tumor+Cells&rft.jtitle=Langmuir&rft.au=Huang%2C+Xin&rft.au=Zhou%2C+Hang&rft.au=Jiao%2C+Rong&rft.au=Liu%2C+Hanrui&rft.date=2021-05-11&rft.pub=American+Chemical+Society&rft.issn=0743-7463&rft.eissn=1520-5827&rft.volume=37&rft.issue=18&rft.spage=5475&rft.epage=5482&rft_id=info:doi/10.1021%2Facs.langmuir.0c03603&rft.externalDocID=b370380546 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0743-7463&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0743-7463&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0743-7463&client=summon |