Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target - Watson, Gabrielle M; Kulkarni, Ketav; Sang, Jianrong; Ma, Xiuquan; Gunzburg, Menachem J; Perlmutter, Patrick; Wilce, Matthew C.J; Wilce, Jacqueline A (Journal of medicinal chemistry, 2017)
Keywords: Cell Line, Tumor; Chemistry, Medicinal; Crystallography, X-Ray; Drug Discovery; Focal Adhesion Kinase 1 - metabolism; GRB7 Adaptor Protein - antagonists & inhibitors; GRB7 Adaptor Protein - chemistry; GRB7 Adaptor Protein - metabolism; Humans; Lactams - chemical synthesis; Lactams - chemistry; Lactams - pharmacology; Life Sciences & Biomedicine; Ligands; Peptides, Cyclic - chemical synthesis; Peptides, Cyclic - chemistry; Peptides, Cyclic - pharmacology; Pharmacology & Pharmacy; Phosphates - chemistry; Protein Conformation; Receptor, ErbB-2 - metabolism; Science & Technology; Shc Signaling Adaptor Proteins - metabolism; src Homology Domains; BREAST-CANCER; SH2 DOMAIN; SIGNAL-TRANSDUCTION; PHOSPHATE; COMPLEX; PROTEIN; AFFINITY; VALIDATION; RECEPTOR; MOLECULES