An Intelligent DNA Nanorobot with in Vitro Enhanced Protein Lysosomal Degradation of HER2

• Published in: Nano letters Vol. 19; no. 7; pp. 4505 - 4517
• Main Authors: Ma, Wenjuan, Zhan, Yuxi, Zhang, Yuxin, Shao, Xiaoru, Xie, Xueping, Mao, Chenchen, Cui, Weitong, Li, Qian, Shi, Jiye, Li, Jiang, Fan, Chunhai, Lin, Yunfeng
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 10.07.2019
• Subjects: Animals; Aptamers, Nucleotide - chemistry; Aptamers, Nucleotide - pharmacology; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; DNA - chemistry; DNA - pharmacology; Drug Delivery Systems; Endocytosis - drug effects; Female; Humans; Lysosomes - metabolism; Lysosomes - pathology; MCF-7 Cells; Mice; Mice, Nude; Proteolysis - drug effects; Receptor, ErbB-2 - metabolism; Robotics; Xenograft Model Antitumor Assays; breast cancer; DNA nanorobot; HER2; framework nucleic acids; aptamer; lysosome

DNA nanorobots have emerged as new tools for nanomedicine with the potential to ameliorate the delivery and anticancer efficacy of various drugs. DNA nanostructures have been considered one of the most promising nanocarriers. In the present study, we report a DNA framework-based intelligent DNA nano...