High Gene Transfer by the Osmotic Polysorbitol-Mediated Transporter through the Selective Caveolae Endocytic Pathway

• Published in: Molecular pharmaceutics Vol. 9; no. 8; pp. 2206 - 2218
• Main Authors: Luu, Quynh-Phuong, Shin, Ji-Young, Kim, You-Kyoung, Islam, Mohammad Ariful, Kang, Sang-Kee, Cho, Myung-Haing, Choi, Yun-Jaie, Cho, Chong-Su
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 06.08.2012
• Subjects: Animals; Cell Line, Tumor; Endocytosis - physiology; Flow Cytometry; Gene Transfer Techniques; HeLa Cells; Humans; Male; Mice; Osmosis; Polyesters - chemistry; Polyesters - metabolism; Polyethyleneimine - analogs & derivatives; Polyethyleneimine - chemistry; Polyethyleneimine - metabolism; Transfection - methods; endocytic pathway; gene transfer; caveolae; transporter; polysorbitol

Cationic polymers have been the subject of intense research as nonviral gene delivery systems due to several advantages in comparison with viral vectors. However, the nonsimultaneous combination of high transfection efficiency and low cytotoxicity of nonviral vectors for gene delivery has long been...