Structure–Activity Relationship Studies of Pyridine-Based Ligands and Identification of a Fluorinated Derivative for Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors - Haider, Achi; Kretz, Julian; Gobbi, Luca; Ahmed, Hazem; Atz, Kenneth; Bürkler, Markus; Bartelmus, Christian; Fingerle, Jürgen; Guba, Wolfgang; Ullmer, Christoph; Honer, Michael; Knuesel, Irene; et al. (Journal of medicinal chemistry, 2019)
Keywords: Animals; Brain - diagnostic imaging; Brain - metabolism; Chemistry, Medicinal; Cyclic AMP - metabolism; Fluorine Radioisotopes - chemistry; Fluorine Radioisotopes - metabolism; Hepatocytes - metabolism; Humans; Life Sciences & Biomedicine; Ligands; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Neuroimaging - methods; Pharmacology & Pharmacy; Positron-Emission Tomography - methods; Protein Conformation; Pyridines - chemistry; Radiochemistry; Radiopharmaceuticals - chemistry; Radiopharmaceuticals - metabolism; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2 - chemistry; Receptor, Cannabinoid, CB2 - metabolism; Science & Technology; Structure-Activity Relationship; TARGET; CB2 RECEPTORS; RADIOLIGAND; VIVO EVALUATION; HIGH-AFFINITY; BINDING; AGONIST