Long-term Exercise and Atherogenic Activity of Blood Mononuclear Cells in Persons at Risk of Developing Ischemic Heart Disease

• Published in: JAMA : the journal of the American Medical Association Vol. 281; no. 18; pp. 1722 - 1727
• Main Authors: Smith, J. Kelly, Dykes, Rhesa, Douglas, John E, Krishnaswamy, Guha, Berk, Steven
• Format: Journal Article
• Language: English
• Published: Chicago, IL American Medical Association 12.05.1999
• Subjects: Arteriosclerosis - immunology; Biological and medical sciences; C-Reactive Protein - analysis; Cardiology. Vascular system; Cardiovascular disease; Coronary heart disease; Cytokines; Cytokines - biosynthesis; Cytokines - blood; Exercise; Exercise - physiology; Female; Health risk assessment; Heart; Humans; Immunophenotyping; Leukocytes, Mononuclear - immunology; Lymphocyte Activation; Male; Medical research; Medical sciences; Middle Aged; Myocardial Ischemia - immunology; Risk; Physical exercise; Human; Biochemical analysis; Cytokine; Cardiovascular disease; Phytohemagglutinin; Coronary heart disease; Long term; Dose activity relation; Prevention; Mononuclear cell; Follow up study; Transforming growth factor β1; C reactive protein

CONTEXT Increasing evidence demonstrates that atherosclerosis is an immunologically mediated disease in which the secretion of atherogenic and atheroprotective cytokines, by infiltrating blood mononuclear cells, plays an important role. It is not known whether long-term exercise alters this atheroge...