Novel Biphasic In Vitro Dissolution Method Correctly Predicts the Oral Bioavailability of Curcumin in Humans

• Published in: Journal of agricultural and food chemistry Vol. 71; no. 42; pp. 15632 - 15643
• Main Authors: Brenner, Marvin Benedikt, Flory, Sandra, Wüst, Matthias, Frank, Jan, Wagner, Karl
• Format: Journal Article
• Language: English
• Published: American Chemical Society 25.10.2023
• Subjects: Bioactive Constituents, Metabolites, and Functions; bioavailability; curcumin; food chemistry; humans; pharmacokinetics; pharmacokinetics; in vitro–in vivo relationship; biphasic dissolution; bioavailability; curcumin formulations

In vitro dissolution methods correctly predicting in vivo bioavailability of compounds from complex mixtures are lacking. We therefore used data on the in vivo performance of bioavailability-improved curcumin formulations to implement an in vivo predictive dissolution method (BiPHa+). BiPHa+ was app...