Design, Synthesis, and Mechanism of Antiviral Acylurea Derivatives Containing a Trifluoromethylpyridine Moiety

• Published in: Journal of agricultural and food chemistry Vol. 69; no. 43; pp. 12891 - 12899
• Main Authors: Guo, Shengxin, Zhao, Wei, Wang, Yanyan, Zhang, Wei, Chen, Shunhong, Wei, Panpan, Wu, Jian
• Format: Journal Article
• Language: English
• Published: American Chemical Society 03.11.2021
• Subjects: amides; antiviral properties; coat proteins; food chemistry; Functional Structure/Activity Relationships; Gibbs free energy; moieties; molecular dynamics; RNA; Tobacco mosaic virus; transmission electron microscopy; acylurea; antivirals; anthranilic diamide; tobacco mosaic virus; trifluoromethylpyridine; preliminary mechanism

Novel acylurea derivatives 7a–7ab were designed and synthesized by linking the active substructures trifluoromethylpyridine and anthranilic diamide via an acylurea bridge. Most of the title compounds exhibited good activity against tobacco mosaic virus (TMV), particularly compound 7x (EC50 of 211.8...