Advances in C–CN Bond Formation via C–H Bond Activation

The cyano group is well known as a versatile intermediate for transformations into a multitude of useful functional groups such as carboxyl, carbamoyl, aminomethyl, carbonyl, and heterocycles. Moreover, benzonitriles and α-aminonitriles are practical synthetic and natural scaffolds. This paper revie...

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Bibliographic Details
Published inACS catalysis Vol. 6; no. 9; pp. 5989 - 6005
Main Authors Ping, Yuanyuan, Ding, Qiuping, Peng, Yiyuan
Format Journal Article
LanguageEnglish
Published American Chemical Society 02.09.2016
Subjects
and cyano-group sources
cyanation
benzonitriles
arenes
α-aminonitriles
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Summary:The cyano group is well known as a versatile intermediate for transformations into a multitude of useful functional groups such as carboxyl, carbamoyl, aminomethyl, carbonyl, and heterocycles. Moreover, benzonitriles and α-aminonitriles are practical synthetic and natural scaffolds. This paper reviews catalytic methodologies for direct cyanation reactions of C–H bonds. These are classified by the cyano-group sources and are sorted into three categories: (i) organic cyano-group sources, (ii) metallic cyano-group sources, and (iii) combined cyano-group sources. This review includes all the reported methods in the literature until the beginning of 2016.
ISSN:2155-5435
2155-5435
DOI:10.1021/acscatal.6b01632