Characterization of Cytochrome P450-Mediated Bioactivation of a Compound Containing the Chemical Scaffold, 4,5-Dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide), to a Chemically Reactive p-Chlorophenyl Isocyanate Intermediate in Human Liver Microsomes - Chen, Hao; Zientek, Michael; Jalaie, Mehran; Zhang, Yanhua; Bigge, Christopher; Mutlib, Abdul (Chemical research in toxicology, 2009)
Keywords: Catalytic Domain; Chlorobenzenes - chemistry; Chlorobenzenes - metabolism; Chlorobenzenes - urine; Chromatography, High Pressure Liquid; Computer Simulation; Cytochrome P-450 CYP3A - metabolism; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - pharmacology; Humans; Isocyanates - chemistry; Isocyanates - metabolism; Kinetics; Microsomes, Liver - metabolism; Pyrazoles - chemistry; Pyrazoles - metabolism; Pyrazoles - urine; Pyrones - chemistry; Pyrones - metabolism; Pyrones - urine; Quantum Theory; Spectrometry, Mass, Electrospray Ionization