Construction of Axially Chiral Biaryls via Atroposelective ortho-C–H Arylation of Aryl Iodides

• Published in: ACS catalysis Vol. 13; no. 5; pp. 2968 - 2980
• Main Authors: Liu, Ze-Shui, Deng, Shuang, Gao, Qianwen, Hua, Yu, Cheng, Hong-Gang, Qi, Xiaotian, Zhou, Qianghui
• Format: Journal Article
• Language: English
• Published: American Chemical Society 03.03.2023
• Subjects: axial chirality; chiral norbornene; C−H arylation; Catellani reaction; chirality transfer; cooperative catalysis; axially chiral biaryls

Due to the dichotomy between reactivity and stereoselectivity, the synthesis of axially chiral biaryls via enantioselective C–H arylation remains a daunting challenge. This full account describes the development of a general and modular platform for the construction of axial chirality through atropo...