Definition of Design Spaces Using Mechanistic Models and Geometric Projections of Probability Maps

• Published in: Organic process research & development Vol. 19; no. 8; pp. 1012 - 1023
• Main Authors: García-Muñoz, Salvador, Luciani, Carla V, Vaidyaraman, Shankar, Seibert, Kevin D
• Format: Journal Article
• Language: English
• Published: American Chemical Society 21.08.2015

Following a model-centric strategy in the development of a manufacturing process for a new medicine empowers the simultaneous study of a large number of process parameters, which is large enough to exceed the capability of a graphic representation of the interactions across them. This work presents...